Microglia have emerged as important players in brain aging and pathology. To understand
how genetic risk for neurological and psychiatric disorders is related to microglial function …

Advances in human genetics have implicated a growing number of genes in
neurodegenerative diseases, providing insight into pathological processes. For Alzheimer …

Microglia are emerging as a key cell type in neurodegenerative diseases, yet human
microglia are challenging to study in vitro. We developed an in vitro cell model system …

Microglia are brain myeloid cells that play a critical role in neuroimmunity and the etiology of
Alzheimer's disease (AD), yet our understanding of how the genetic regulatory landscape …

INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks …

Growing recognition of the pivotal role microglia play in neurodegenerative and
neuroinflammatory disorders has accentuated the need to characterize their function in …

Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease
(AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene …

The morphological plasticity of microglia has fascinated neuroscientists for 100 years.
Attempts to classify functional phenotypes are hampered by similarities between …

Microglia have fundamental roles in health and disease; however, effects of age, sex, and
genetic factors on human microglia have not been fully explored. We applied bulk and …

With a rapidly aging global human population, finding a cure for late onset
neurodegenerative diseases has become an urgent enterprise. However, these efforts are …