Rosiglitazone protects against acetaminophen‐induced acute liver injury by inhibiting multiple endoplasmic reticulum stress pathways
Y Cao, W He, X Li, J Huang… - BioMed Research …, 2022 - Wiley Online Library
Background. Excessive acetaminophen (APAP) use can lead to acute liver injury (ALI) by
inducing endoplasmic reticulum stress (ERS). We previously found that pretreatment with …
inducing endoplasmic reticulum stress (ERS). We previously found that pretreatment with …
Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases
JX Wang, C Zhang, L Fu, DG Zhang, BW Wang… - Toxicology Letters, 2017 - Elsevier
The peroxisome proliferator-activated receptor gamma (PPAR-γ) is a ligand-activated
nuclear receptor that regulates glucose and lipid metabolism. The aim of the present study …
nuclear receptor that regulates glucose and lipid metabolism. The aim of the present study …
Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure
L Zhang, F Ren, X Zhang, X Wang… - Disease models & …, 2016 - journals.biologists.com
Peroxisome proliferator-activated receptor α (PPARα) is a key regulator to ameliorate liver
injury in cases of acute liver failure (ALF). However, its regulatory mechanisms remain …
injury in cases of acute liver failure (ALF). However, its regulatory mechanisms remain …
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress
H Kusama, K Kon, K Ikejima, K Arai, T Aoyama… - Journal of …, 2017 - Springer
Background Acetaminophen (APAP) overdose induces severe oxidative stress followed by
hepatocyte apoptosis/necrosis. Previous studies have indicated that endoplasmic reticulum …
hepatocyte apoptosis/necrosis. Previous studies have indicated that endoplasmic reticulum …
Protective effect of water-soluble acacetin prodrug on APAP-induced acute liver injury is associated with upregulation of PPARγ and alleviation of ER stress
J Miao, S Yao, H Sun, Z Jiang, Z Gao, J Xu… - International Journal of …, 2023 - mdpi.com
A water-soluble acacetin prodrug has been synthesized and reported by our group
previously. Acetaminophen (APAP) overdose is a leading cause of acute liver injury. We …
previously. Acetaminophen (APAP) overdose is a leading cause of acute liver injury. We …
Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice
Hepatotoxicity induced by acetaminophen (APAP)‐overdose is a major concern in clinical
practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced …
practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced …
Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways
J Tian, S Zhang, L Li, X Lin, Y Li… - Experimental …, 2023 - journals.sagepub.com
Excessive acetaminophen (APAP) application is a major cause of drug-induced liver injury
(DILI). Febuxostat (Feb), a drug for reducing uric acid (UA) levels, was demonstrated to …
(DILI). Febuxostat (Feb), a drug for reducing uric acid (UA) levels, was demonstrated to …
[PDF][PDF] Benzyl alcohol attenuates acetaminophen‐induced acute liver injury in a Toll‐like receptor‐4‐dependent pattern in mice
C Cai, H Huang, S Whelan, L Liu, B Kautza… - …, 2014 - Wiley Online Library
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure in
industrialized countries. Understanding the mechanisms of APAP‐induced liver injury as …
industrialized countries. Understanding the mechanisms of APAP‐induced liver injury as …
ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling
Y Luo, Y Lei, H Zhou, Y Chen, H Liu, J Jiang… - Cell Biology and …, 2024 - Springer
Acetaminophen (APAP) stands as the predominant contributor to drug-induced liver injury
(DILI), and limited options are available. β-Arrestin1 (ARRB1) is involved in numerous liver …
(DILI), and limited options are available. β-Arrestin1 (ARRB1) is involved in numerous liver …
[HTML][HTML] Disruption of peroxisome proliferator-activated receptor α in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 …
Z Zhang, T Yao, N Zhao, H Liu, H Cheng… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Background & Aims: Peroxisome proliferator-activated receptor α (PPARα) is a ligand-
activated transcription factor abundantly expressed in liver. PPARα activator has been …
activated transcription factor abundantly expressed in liver. PPARα activator has been …