Background. Excessive acetaminophen (APAP) use can lead to acute liver injury (ALI) by
inducing endoplasmic reticulum stress (ERS). We previously found that pretreatment with …

The peroxisome proliferator-activated receptor gamma (PPAR-γ) is a ligand-activated
nuclear receptor that regulates glucose and lipid metabolism. The aim of the present study …

Peroxisome proliferator-activated receptor α (PPARα) is a key regulator to ameliorate liver
injury in cases of acute liver failure (ALF). However, its regulatory mechanisms remain …

Background Acetaminophen (APAP) overdose induces severe oxidative stress followed by
hepatocyte apoptosis/necrosis. Previous studies have indicated that endoplasmic reticulum …

A water-soluble acacetin prodrug has been synthesized and reported by our group
previously. Acetaminophen (APAP) overdose is a leading cause of acute liver injury. We …

Hepatotoxicity induced by acetaminophen (APAP)‐overdose is a major concern in clinical
practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced …

Excessive acetaminophen (APAP) application is a major cause of drug-induced liver injury
(DILI). Febuxostat (Feb), a drug for reducing uric acid (UA) levels, was demonstrated to …

Acetaminophen (APAP) toxicity is the most common cause of acute liver failure in
industrialized countries. Understanding the mechanisms of APAP‐induced liver injury as …

Acetaminophen (APAP) stands as the predominant contributor to drug-induced liver injury
(DILI), and limited options are available. β-Arrestin1 (ARRB1) is involved in numerous liver …

Background & Aims: Peroxisome proliferator-activated receptor α (PPARα) is a ligand-
activated transcription factor abundantly expressed in liver. PPARα activator has been …