Overcoming the low oral bioavailability of many drugs due to their poor aqueous solubility is
one of the major challenges in the pharmaceutical industry. The production of amorphous …

Amorphous solid dispersions (ASDs) can phase separate in the gel phase during
dissolution, lowering the chemical potential and thus the driving force for drug release. The …

Purpose The oral bioavailability of poorly water-soluble active pharmaceutical ingredients
(APIs) can be improved by the preparation of amorphous solid dispersions (ASDs) where …

The maximum achievable concentration of a drug in solution is dictated by the chemical
potential of the solid form. Because an amorphous solid has a higher chemical potential …

Amorphous solid dispersions (ASDs) represent an important formulation technique to
achieve supersaturation in gastrointestinal fluids and to enhance absorption of poorly water …

Amorphous engineered particle compositions of itraconazole (ITZ) and potential
concentration enhancing polymers, cellulose acetate phthalate (CAP) and polyvinyl acetate …

This work evaluates several compositions of an amorphous solid dispersion (ASD)
comprising nimodipine (NMD) as poorly soluble model API in a dual-polymer carrier system …

Amorphous solid dispersion (ASD) is one of the most promising strategies for improving the
solubility of active pharmaceutical ingredients (APIs) with low aqueous solubility. Solvent …

Abstract Although Amorphous Solid Dispersions (ASDs) effectively increase bioavailability,
tablet mass can be high due to the large fraction of excipients needed to stabilize the …

Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …