Thirty-four dogs were given tritium-labeled digoxin intravenously. Serum and tissue
concentrations and half-times were determined. As demonstrated previously in human …

Ten patients were digitalized by the intramuscular route with tritium-labeled digoxin.
Radioactivity levels of the serum, urine and stools were studied for seven days. Serum …

Linear correlation was demonstrated between serum digoxin and papillary muscle digoxin
concentrations in patients undergoing mitral valve surgery. The mean ratio of myocardial …

Biopsies of cardiac tissue were taken from patients undergoing surgery for coronary artery or
valvular disease. All subjects were on maintenance doses of digoxin, which were stopped …

Guinea-pig and rat hearts were perfused via the aorta at constant flow with 10-7 M digoxin-
H3 for periods up to 64 min. The temperature was 28° C. The hearts were then perfused for …

Glycoside concentrations in plasma and various tissues of dogs were determined after a
single and repeated intravenous administration of tritium-labeled digoxin and [beta] …

The criteria which a drug must fulfil before it can be said that it may be worthwhile making
regular plasma concentration measurements of that drug in monitoring therapy are …

The methods of dextran gel filtration and membrane dialysis were utilized to demonstrate the
small amount of in vivo human serum protein binding of tritiated digoxin. The biologic and …

Digoxin concentmtions in serum and left ventricular tissue were measured at autopsy and
related to estimated antemortem creatinine clearances in 15 patients. A significant …

The relation between myocardial digoxin concentration and its nemodynamic effects in the
same animal was studied in 23 open chest anesthetized dogs with intact circulations given …