Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Inflammatory caspases play a central role in innate immunity by responding to cytosolic
signals and initiating a twofold response. First, caspase‐1 induces the activation and …

Pyroptosis is a form of lytic, programmed cell death that functions as an innate immune
effector mechanism to facilitate host defense against pathogenic microorganisms, including …

Immune cells and skin and mucosal epithelial cells recognize invasive microbes and other
signs of danger to sound alarms that recruit responder cells and initiate an immediate …

Pyroptosis is a newly discovered programmed cell death with inflammasome formation.
Pattern recognition receptors that identify repetitive motifs of prospective pathogens such as …

Inflammasomes are innate immune mechanisms that promote inflammation by activating the
protease caspase‐1. Active caspase‐1 induces pyroptosis, a necrotic form of regulated cell …

Programmed cell death is a necessary part of development and tissue homeostasis
enabling the removal of unwanted cells. In the setting of infectious disease, cells that have …

Pyroptosis is the caspase-dependent inflammatory cell death mechanism that underpins the
innate immune response against pathogens and is dysregulated in inflammatory disorders …

Sepsis is recognized as a life‐threatening organ dysfunctional disease that is caused by
dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause …

Pyroptosis, a type of programmed cell death mediated by gasdermin, is characterized by the
swelling and rupture of cells, release of cellular contents and a strong inflammatory …