The protein toxin C3bot from Clostridium botulinum is a mono-ADP-ribosyltransferase that
selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and …

Background The C3bot1 protein (∼ 23 kDa) from Clostridium botulinum ADP-ribosylates
and thereby inactivates Rho. C3bot1 is selectively taken up into the cytosol of monocytes …

The C3 toxin produced by Clostridium botulinum (C3bot) catalyzes the mono-ADP-
ribosylation of the small GTPases Rho A, B and C, resulting in their inactivation. Recently, a …

We demonstrated previously that monocytes and macrophages are target cells for the Rho-
modifying Clostridium botulinum C3 ADP-ribosyltransferase. Here, we report the …

C3 protein toxins produced by Clostridium (C.) botulinum and C. limosum are mono-ADP-
ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of …

Clostridium botulinum C3 is the prototype of C3-like ADP-ribosyltransferases that selectively
ADP-ribosylate the small GTP-binding proteins RhoA/B/C and inhibit their downstream …

The Clostridium botulinum C3 exoenzyme selectively ADP-ribosylates low molecular weight
GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling …

The binary Clostridium (C.) botulinum C2 toxin consists of two non-linked proteins. The
proteolytically activated binding/transport subunit C2IIa forms barrel-shaped …

The C2 toxin of Clostridium botulinum is a binary bacterial protein toxin, comprising the
enzyme component C2I and the separate binding/translocation component C2IIa. C2IIa …

The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the
enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects …