[HTML][HTML] Clostridium botulinum C3 toxin for selective delivery of cargo into dendritic cells and macrophages
M Fellermann, M Stemmer, R Noschka, F Wondany… - Toxins, 2022 - mdpi.com
The protein toxin C3bot from Clostridium botulinum is a mono-ADP-ribosyltransferase that
selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and …
selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and …
A recombinant fusion toxin based on enzymatic inactive C3bot1 selectively targets macrophages
L Dmochewitz, C Förtsch, C Zwerger, M Vaeth… - PLoS …, 2013 - journals.plos.org
Background The C3bot1 protein (∼ 23 kDa) from Clostridium botulinum ADP-ribosylates
and thereby inactivates Rho. C3bot1 is selectively taken up into the cytosol of monocytes …
and thereby inactivates Rho. C3bot1 is selectively taken up into the cytosol of monocytes …
Streptavidin-conjugated C3 protein mediates the delivery of mono-biotinylated RNAse A into macrophages
The C3 toxin produced by Clostridium botulinum (C3bot) catalyzes the mono-ADP-
ribosylation of the small GTPases Rho A, B and C, resulting in their inactivation. Recently, a …
ribosylation of the small GTPases Rho A, B and C, resulting in their inactivation. Recently, a …
Recombinant streptavidin-C3bot for delivery of proteins into macrophages
H Christow, M Lillich, A Sold, J Fahrer, H Barth - Toxicon, 2013 - Elsevier
We demonstrated previously that monocytes and macrophages are target cells for the Rho-
modifying Clostridium botulinum C3 ADP-ribosyltransferase. Here, we report the …
modifying Clostridium botulinum C3 ADP-ribosyltransferase. Here, we report the …
Clostridial C3 toxins enter and intoxicate human dendritic cells
M Fellermann, C Huchler, L Fechter, T Kolb… - Toxins, 2020 - mdpi.com
C3 protein toxins produced by Clostridium (C.) botulinum and C. limosum are mono-ADP-
ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of …
ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of …
Cell Entry of C3 Exoenzyme from Clostridium botulinum
A Rohrbeck, I Just - Uptake and Trafficking of Protein Toxins, 2017 - Springer
Clostridium botulinum C3 is the prototype of C3-like ADP-ribosyltransferases that selectively
ADP-ribosylate the small GTP-binding proteins RhoA/B/C and inhibit their downstream …
ADP-ribosylate the small GTP-binding proteins RhoA/B/C and inhibit their downstream …
[HTML][HTML] Uptake of Clostridium botulinum C3 exoenzyme into intact HT22 and J774A. 1 cells
A Rohrbeck, L Von Elsner, S Hagemann, I Just - Toxins, 2015 - mdpi.com
The Clostridium botulinum C3 exoenzyme selectively ADP-ribosylates low molecular weight
GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling …
GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling …
The Clostridium botulinum C2 Toxin Subunit C2IIa Delivers Enzymes with Positively Charged N-Termini into the Cytosol of Target Cells
S Heber, J Borho, N Stadler, F Wondany, I König… - Toxins, 2023 - mdpi.com
The binary Clostridium (C.) botulinum C2 toxin consists of two non-linked proteins. The
proteolytically activated binding/transport subunit C2IIa forms barrel-shaped …
proteolytically activated binding/transport subunit C2IIa forms barrel-shaped …
Genetically engineered clostridial C2 toxin as a novel delivery system for living mammalian cells
J Fahrer, R Plunien, U Binder, T Langer… - Bioconjugate …, 2010 - ACS Publications
The C2 toxin of Clostridium botulinum is a binary bacterial protein toxin, comprising the
enzyme component C2I and the separate binding/translocation component C2IIa. C2IIa …
enzyme component C2I and the separate binding/translocation component C2IIa. C2IIa …
The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes
J Eisele, S Schreiner, J Borho, S Fischer… - Frontiers in …, 2022 - frontiersin.org
The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the
enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects …
enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects …