The binary Clostridium botulinum C2 toxin consists of two separate proteins, the binding
component C2II (80.5 kDa) and the actin-ADP-ribosylating enzyme component C2I (49.4 …

Binary toxins are produced by several pathogenic bacteria. Examples are the C2 toxin from
Clostridium botulinum, the iota toxin from Clostridium perfringens, and the CDT from …

Targeted transfection of the CNS with synthetic, nonviral vectors represents a huge technical
challenge. The approach explored here attempts to combine self‐assembly ABCD …

Botulinum neurotoxins (BoNTs) deliver a protease to neurons which can cause a flaccid
paralysis called botulism. Development of botulism antidotes will require neuronal delivery …

Over the last few decades, proteins and peptides have become increasingly more common
as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the …

Binary bacterial toxins are unique AB-type toxins, composed of two non-linked proteins that
act as a binding/translocation component and an enzyme component. All known actin-ADP …

Mono ADP-ribosylation is a common characteristic of bacterial toxins resulting to aberrant
activation or inactivation of target proteins. The C3 exoenzyme of Clostridium botulinum …

Botulinum neurotoxin (BoNT) A and B are used to treat neuropathic disorders; if retargeted,
these agents could be used to treat medical conditions that involve secretion from …

C3 from Clostridium botulinum (C3) specifically modifies Rho GTPases RhoA, RhoB, and
RhoC by mono-ADP-ribosylation. The confined substrate profile of C3 is the basis for its use …

The binary Clostridium botulinum C2 toxin is composed of the enzyme component C2I and
the binding component C2II, which are individual and non-linked proteins. Activated C2IIa …