Abstract Associations of P16, MGMT, hMLH1 and hMLH2 with gastric cancer and their
relation with MTHFR status in gastric patients who were confirmed with pathological …

Aim: The present case-control study was conducted to explore the association of MTHFR
gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake …

Objective: We aimed to explore the association of P16, MGMT and HMLH1 with gastric
cancer and their relation with Methylenetetrahydrofolate reductase (MTHFR). Methods: 322 …

Methylenetetrahydrofolate reductase (MTHFR) has been reported to be associated with
DNA methylation, anepigenetic feature frequently found in gastric cancer. We conducted a …

To explore the role of aberrant hypermethylation of cancer-related genes, such as P16,
MGMT, and hMLH1, in the esophageal squamous cell carcinoma (ESCC) as well as its …

Epidemiological studies have indicated that folate metabolism is correlated with increased
risk of gastric cancer. Since methylenetetrahydrofolate reductase (MTHFR) is an important …

Cancer is a multi-factorial disease and variation in genetic susceptibility, due to inherited
differences in thecapacity to repair mismatches in the genome, is an important factor in the …

AIM: Hypermethylation of the promoter of the hMLH1 gene, which plays an important role in
mismatch repair during DNA replication, occurs in more than 30% of human gastric cancer …

Background: Genetic and environmental factors play important roles in pathogenesis of
digestive tract cancers like those in the esophagus, stomach and colorectum. Folate …

Background: DNA methyltransferase-3a (DNMT3a) plays significant roles in embryogenesis
and the generation of aberrant methylation in carcinogenesis. This study aimed to …