Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
The inflammasomes are signaling platforms that promote the activation of inflammatory
caspases such as caspases-1,-4,-5, and-11. Recent studies identified gasdermin D …
caspases such as caspases-1,-4,-5, and-11. Recent studies identified gasdermin D …
Inflammatory caspases: activation and cleavage of gasdermin-D in vitro and during pyroptosis
Gasdermin-D (also known as GSDMD), the newly identified executioner of pyroptotic cell
death, is cleaved by activated caspase-1 downstream of canonical inflammasome activation …
death, is cleaved by activated caspase-1 downstream of canonical inflammasome activation …
Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage
The recognition and cleavage of gasdermin D (GSDMD) by inflammatory caspases-1, 4, 5,
and 11 are essential steps in initiating pyroptosis after inflammasome activation. Previous …
and 11 are essential steps in initiating pyroptosis after inflammasome activation. Previous …
The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11
Inflammatory pathways usually utilize negative feedback regulatory systems to prevent
tissue damage arising from excessive inflammatory response. Whether such negative …
tissue damage arising from excessive inflammatory response. Whether such negative …
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
CL Evavold, I Hafner-Bratkovič, P Devant, JM D'Andrea… - Cell, 2021 - cell.com
The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death
A Weir, JE Vince - Biochemical Journal, 2022 - portlandpress.com
For over 15 years the lytic cell death termed pyroptosis was defined by its dependency on
the inflammatory caspase, caspase-1, which, upon pathogen sensing, is activated by innate …
the inflammatory caspase, caspase-1, which, upon pathogen sensing, is activated by innate …
Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases
F Lu, Z Lan, Z Xin, C He, Z Guo… - Journal of cellular …, 2020 - Wiley Online Library
Pyroptosis is a form of necrotic and inflammatory programmed cell death, which could be
characterized by cell swelling, pore formation on plasma membranes, and release of …
characterized by cell swelling, pore formation on plasma membranes, and release of …
Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein
gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here …
gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here …
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
L Sborgi, S Rühl, E Mulvihill, J Pipercevic… - The EMBO …, 2016 - embopress.org
Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These
caspases are activated within multi‐protein inflammasome complexes that assemble in …
caspases are activated within multi‐protein inflammasome complexes that assemble in …
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
Inflammasome is an intracellular signaling complex of the innate immune system. Activation
of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers …
of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers …