The importance of inflammation as a driver of pathology is no longer confined to
autoimmune and infectious diseases. In line with convincing experimental data as well as …

Our current understanding of the vascular biology of atherogenesis and its clinical
manifestations suggests a pathophysiology that is much more complex than mere lipid …

Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. In
atherosclerotic lesions, macrophages respond to various environmental stimuli, such as …

Atherosclerosis is still an important disease. It accounts for 39% of deaths in the UK and 12
million US citizens have atherosclerosis-associated disease. Atherosclerosis may exert …

Sound data support the concept that in atherosclerosis, inflammation and dyslipidemia
intersect each other and that irrespective of the initiator, both participate from the early …

Purpose Cardiovascular disease (CVD) is the leading cause of death, globally, and its
prevalence is only expected to rise due to the increasing incidence of co-morbidities such as …

Inflammation plays an important role in the initiation and progression of atherosclerosis but
many of its underlying mechanisms remain to be explored. Atherosclerotic plaques which …

Atherosclerosis is a pathological process that takes place in the major arteries and is the
underlying cause of heart attacks, stroke and peripheral artery disease. The earliest …

Physical disruption of atheroma frequently causes coronary thrombosis. Ruptured plaques
usually have thin fibrous caps overlying a large thrombogenic lipid core rich in lipid-laden …

Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …