Inflammatory cytokines are well-recognized mediators of atherosclerosis. Depending on the
pathological context, type I interferons (IFNs; IFNα and IFNβ) exert either pro-or anti …

Atherosclerosis (AS) is the main pathological basis of cardiovascular diseases, which is
mainly characterized by lipid deposition and inflammatory response. Macrophages (MΦ), as …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Macrophages are becoming increasingly recognized as key agents in chronic diseases of
aging, including cancer, metabolic disease, and, the topic of this review, atherosclerosis. In …

Diversity and plasticity are hallmarks of mononuclear phagocytes, which are reflected in
plaque formation and evolution. Different monocyte subsets, which differentially contribute to …

Atherogenic cofactors, such as altered cholesterol metabolism, may impact locally on
inflammatory responses in atherosclerotic lesions. Blood levels of inflammatory markers (eg …

Interleukins (ILs) are key mediators in the chronic vascular inflammatory response
underlying several aspects of cardiovascular disease. Due to their powerful pro …

Inflammation plays a key role in the pathogenesis of atherosclerosis. The more we discover
about the molecular pathways involved in atherosclerosis, the more we perceive the …

Atherosclerosis is a chronic inflammatory disease of the vasculature with lesions developing
in the arterial wall, frequently in the coronary and carotid arteries. The interaction between …

The pro-oxidative and pro-inflammatory pathways in vascular endothelium have been
implicated in the initiation and progression of atherosclerosis. In fact, inflammatory …