Monoclonal antibodies (Mab) have deJined fimclional T lymphoo, te subsets in mouse and
man: Ly-1/OKTd positive helper T cells, Ly-19,,]/OKT8 positive kdler T (ells and Ly-2d/OKT8 …

In adult mice, the number of B lymphocytes remains constant under homeostatic control, in
spite of the fact that B cells are produced continuously in numbers that largely exceed the …

Mature B lymphocytes (B cells) recognize antigens using their B cell receptor (BCR) and are
activated to become antibody-producing cells. In addition, and integral to the development of …

B cell recognition of membrane-bound antigens leads to the formation of an immunological
synapse and efficient B cell activation. Ongoing research has been directed towards …

The contribution of B lymphocytes as APCs for CD4+ T cell priming remains controversial,
based on findings that B cells cannot provide the requisite ligating and costimulatory signals …

A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and
functions that are distinct from those of conventional B cells exist in mice. It contributes the …

B lymphocytes are generally recognized for their potential to mediate humoral immunity by
producing different antibody isotypes and being involved in opsonization and complement …

Molecular interactions at the interface between helper T cells and antigen-presenting B cells
govern the ability to produce specific antibodies, which is a central event in protective …

The role of B cells as APC is well established. However, their ability to prime naive T cells in
vivo has been difficult to examine because of the presence of dendritic cells. The current …

ABSTRACT B lymphocytes comprise a major component of the adaptive mammalian
immune system, having the exclusive ability to produce and secrete immunoglobulins (Ig) of …