Guanine nucleotide-binding proteins (G proteins) activate K+ conductances in cardiac atrial
cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three …

We have previously shown that direct binding of the βγ subunit of G protein (Gβγ) to both the
N-terminal domain and the C-terminal domain of a cloned G protein-gated inward-rectifying …

In neuronal and atrial tissue, G protein-gated inwardly rectifying K+ channels (Kir3. x family)
are responsible for mediating inhibitory postsynaptic potentials and slowing the heart rate …

G protein‐activated inwardly rectifying K+ channel subunits GIRK1 (Kir 3.1), GIRK2 (Kir 3.2),
and CIR (Kir 3.4) were expressed individually or in combination in Xenopus oocytes and …

Activation of G protein-gated K÷ channels by G protein-coupled receptors contributes to
parasympathetic regulation of heart rate in the atrium and inhibitory postsynaptic potentials …

G protein-activated K+ channels (Kir3 or GIRK) are activated by direct binding of Gβγ. The
binding sites of Gβγ in the ubiquitous GIRK1 (Kir3. 1) subunit have not been unequivocally …

The cardiac G protein-gated K+ channel, I KACh, is activated by application of purified and
recombinant β and γ subunits (Gβγ) of heterotrimeric G proteins to excised inside-out …

The family of G-protein-activated inward-rectifiers K+ channels presently comprise at least 3
cloned members called GIRK1, GIRK2 and GIRK3. A close structural parent of GIRK …

G protein-coupled inwardly rectifying potassium (GIRK) channels can be activated or
inhibited by different classes of receptors, suggesting a role for G proteins in determining …

G protein-activated K+ channels (GIRKs; Kir3) are activated by direct binding of Gβγ
subunits released from heterotrimeric G proteins. In native tissues, only pertussis toxin …