Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis since Treg
dysfunction in both animals and humans is associated with multi-organ autoimmune and …

Immune homeostasis is heavily dependent on the action of regulatory T cells (Tregs) which
act to suppress the activation of many immune cell types including autoreactive conventional …

FOXP3+ regulatory T cells (Treg) are indispensable for immune homoeostasis and for the
prevention of autoimmune diseases. Interleukin-2 (IL-2) signalling is critical in all aspects of …

Depletion of regulatory T (TReg) cells in otherwise healthy individuals leads to multi-organ
autoimmune disease and inflammation. This indicates that in a normal immune system …

Regulatory T cells (Treg) are crucial for the maintenance of peripheral tolerance and for the
control of ongoing inflammation and autoimmunity. The cytokine interleukin-2 (IL-2) is …

Cytokine signaling is indispensable for regulatory T-cell (Treg) development in the thymus,
and also influences the homeostasis, phenotypic diversity, and function of Tregs in the …

Autoimmune diseases are characterized by dysregulation and aberrant activation of cells in
the immune system. Therefore, restoration of the immune balance represents a promising …

Failure of regulatory T (Treg) cells to properly control immune responses leads invariably to
autoimmunity and organ damage. Decreased numbers or impaired function of Treg cells …

Abstract Interleukin-2 (IL-2) is a pleiotropic cytokine required for both effector lymphocyte
proliferation/differentiation and regulatory T cell expansion/survival. Ability to receive IL-2 …

Stimulation of regulatory T (Treg) cells holds great promise for the treatment of autoimmune,
chronic inflammatory, and certain metabolic diseases. Recent clinical trials with low-dose …