The immune system is tasked with defending the host from a wide array of pathogens and
environmental insults. When uncontrolled, this endeavor may lead to off-target reactivity to …

Immune regulation is a complex process that depends on the maintenance of self tolerance
while retaining robust immune responses against microbes. The emergence of Treg as a …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss
of insulin-producing pancreatic β-cells. The pathogenesis of T1D is complex and …

Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by
self-immune cells, and the consequent inability of the body to maintain insulin levels for …

Type 1 diabetes (T1D) is an autoimmune disease that occurs in genetically susceptible
individuals. Regulatory T cells (Tregs) have been shown to be defective in the autoimmune …

In type 1 diabetes (T1D), insulin-producing pancreatic β-cells are attacked and destroyed by
the immune system. Although man-made insulin is life-saving, it is not a cure and it cannot …

Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of insulin producing
beta cells. Regulatory T cells (Tregs) have been shown to be defective in this setting …

Regulatory T-cells (Tregs) play important role in regulation of immune responses to self-
antigens. Alterations in frequency and function of Tregs have been reported in Type 1 …

T-regulatory cells (Tregs) play a fundamental role in the creation and maintenance of
peripheral tolerance. Deficits in the numbers and/or function of Tregs may be an underlying …

Type 1 diabetes (T1D) is a chronic autoimmune disease that leads to destruction of
pancreatic β cells, lifelong dependence on insulin, and increased morbidity and mortality …