Mitochondrial-derived reactive oxygen species influence ADP sensitivity, but not CPT-I substrate sensitivity

PA Barbeau, PM Miotto, GP Holloway - Biochemical Journal, 2018 - portlandpress.com
The mechanisms regulating oxidative phosphorylation during exercise remain poorly
defined; however, key mitochondrial proteins, including carnitine palmitoyltransferase-I (CPT …

Exercise-induced reductions in mitochondrial ADP sensitivity contribute to the induction of gene expression and mitochondrial biogenesis through enhanced …

PM Miotto, GP Holloway - Mitochondrion, 2019 - Elsevier
Acute exercise rapidly induces mitochondrial gene expression, however, the intracellular
events regulating this process remain incompletely understood. The purpose of this study …

The regulation of mitochondrial substrate utilization during acute exercise

HL Petrick, GP Holloway - Current Opinion in Physiology, 2019 - Elsevier
Highlights•Mitochondrial oxidative energy production is essential during exercise.•Both fat
and carbohydrate contribute to this process based on exercise intensity.•Fuel interactions …

[HTML][HTML] Rapid regulation of substrate use for oxidative phosphorylation during a single session of high intensity interval or aerobic exercises in different rat skeletal …

EL Martins, JC Ricardo, E de-Souza-Ferreira… - … and Physiology Part B …, 2018 - Elsevier
Different exercise protocols lead to long-term adaptations that are related to increased
mitochondrial content through the activation of mitochondrial biogenesis. However …

High‐intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature‐dependent manner in human skeletal muscle …

M Fiorenza, AK Lemminger, M Marker… - The FASEB …, 2019 - Wiley Online Library
The purpose of the present study was to investigate whether exercise training‐induced
adaptations in human skeletal muscle mitochondrial bioenergetics are magnified under …

[HTML][HTML] Nutrition and training influences on the regulation of mitochondrial adenosine diphosphate sensitivity and bioenergetics

GP Holloway - Sports Medicine, 2017 - Springer
Since the seminal finding almost 50 years ago that exercise training increases mitochondrial
content in skeletal muscle, a considerable amount of research has been dedicated to …

[HTML][HTML] Exercise and mitochondrial dynamics: keeping in shape with ROS and AMPK

AJ Trewin, BJ Berry, AP Wojtovich - Antioxidants, 2018 - mdpi.com
Exercise is a robust stimulus for mitochondrial adaptations in skeletal muscle which
consequently plays a central role in enhancing metabolic health. Despite this, the precise …

[HTML][HTML] Exercise is mitochondrial medicine for muscle

AN Oliveira, DA Hood - Sports medicine and health science, 2019 - Elsevier
Mitochondria are vital organelles that provide energy for muscle function. When these
organelles become dysfunctional, they produce less energy as well as excessive levels of …

Eccentric exercise transiently affects mice skeletal muscle mitochondrial function

J Magalhaes, M Fraga, J Lumini-Oliveira… - Applied Physiology …, 2013 - cdnsciencepub.com
Eccentric exercise (EE) is known to induce damage and dysfunction in skeletal muscle.
However, the possible role of mitochondrial (dys) function, including the vulnerability to …

Mitochondria in exercise-induced oxidative stress

S Di Meo, P Venditti - Neurosignals, 2001 - karger.com
In recent years it has been suggested that reactive oxygen species (ROS) are involved in the
damage to muscle and other tissues induced by acute exercise. Despite the small …