Amphipathic silica nanoparticles induce cytotoxicity through oxidative stress mediated and p53 dependent apoptosis pathway in human liver cell line HL-7702 and rat …

D Zuo, Z Duan, Y Jia, T Chu, Q He, J Yuan… - Colloids and Surfaces B …, 2016 - Elsevier
The aim of this study was to evaluate the potential cytotoxicity and the underlying
mechanism of amphipathic silica nanoparticles (SiO 2 NPs) exposure to human normal liver …

Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2

J Ahmad, M Ahamed, MJ Akhtar, SA Alrokayan… - Toxicology and applied …, 2012 - Elsevier
Silica nanoparticles are increasingly utilized in various applications including agriculture
and medicine. In vivo studies have shown that liver is one of the primary target organ of …

Metabolic responses of HeLa cells to silica nanoparticles by NMR-based metabolomic analyses

J Feng, J Li, H Wu, Z Chen - Metabolomics, 2013 - Springer
Silica nanoparticles are increasingly used in the biomedical fields due to their excellent
solubility, high stability and favorable biocompatibility. However, despite being considered of …

In vivo toxicity of orally administrated silicon dioxide nanoparticles in healthy adult mice

R Hassankhani, M Esmaeillou, AA Tehrani… - … Science and Pollution …, 2015 - Springer
The increasing use of silica nanoparticles (SiNPs) in various applications including
industrial, agriculture, and medicine has raised concerns about their potential risks to human …

NMR-based metabonomics study of sub-acute hepatotoxicity induced by silica nanoparticles in rats after intranasal exposure

A Parveen, SHM Rizvi, A Gupta, R Singh… - Cellular and Molecular …, 2012 - cellmolbiol.org
Abstract Silica nanoparticles (SiO2 NPs) are widely used commercially; however, their
potential toxicity on human health has attracted particular attention. In the present study, the …

[HTML][HTML] Silica nanoparticle–induced reproductive toxicity in male albino rats via testicular apoptosis and oxidative stress

RA Azouz, RMS Korany, PA Noshy - Biological Trace Element Research, 2023 - Springer
Amorphous silica nanoparticles (SiNPs) are being utilized in different fields such as
medicine, cosmetics, and foods. However, the causes and mechanisms underlying SiNP …

Silica nanoparticles-induced cytotoxicity, oxidative stress and apoptosis in cultured A431 and A549 cells

M Ahamed - Human & experimental toxicology, 2013 - journals.sagepub.com
In medicine, the use of silica nanoparticles (SiO2 NPs) offers new perspectives in biosensor,
drug delivery and cancer therapy. However, questions about potential toxic and deleterious …

Silica nanoparticles exacerbates reproductive toxicity development in high-fat diet-treated Wistar rats

L Zhang, J Wei, J Duan, C Guo, J Zhang, L Ren… - Journal of hazardous …, 2020 - Elsevier
To demonstrate the combined adverse effect and the mechanism of silica nanoparticles
(SiNPs) with 57.66±7.30 nm average diameter and high-fat diet (HFD) on Wistar rats, 60 …

Study of silymarin and vitamin E protective effects on silver nanoparticle toxicity on mice liver primary cell culture

F Faedmaleki, FH Shirazi, S Ejtemaeimehr, S Anjarani… - 2016 - sid.ir
Nanotechnology is a most promising field for generating new applications in medicine,
although, only few nano products are currently in use for medical purposes. A most …

Toxicity and Genotoxicity of Nano-SiO2 on Human Epithelial Intestinal HT-29 Cell Line

JA Sergent, V Paget, S Chevillard - Annals of occupational …, 2012 - academic.oup.com
Silica mesoporous nanoparticles have been recently selected for a wide range of
applications from electronics to medicine due to their intrinsic properties. Among medical …