Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions
among neighboring cells and thus facilitates gap junctional intercellular communication …

The expression, localization, and function of connexins, the protein subunits that comprise
gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Importance of the field: Connexins (Cxs) and gap junctional intercellular communications
(GJICs) play roles in cancer development, growth and metastasis. Experimental studies …

Despite concerted clinical and research efforts, cancer is a leading cause of death
worldwide. Surgery, radiation, and chemotherapy have remained the most common …

Gap junctions are intercellular plasma membrane domains enriched in channels that allow
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …

Connexins (Cx) are members of a protein family that forms intercellular channels localised in
gap junction (GJ) plaques and single transmembrane channels called hemichannels. They …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …

Connexins have long been believed to suppress tumour development during
carcinogenesis by exerting gap junctional intercellular communication (GJIC). Although …