Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an
increased risk of myeloid malignancies. We performed an integrative characterization of …

The functional potential of hematopoietic stem cells (HSCs) declines during aging, and in
doing so, significantly contributes to hematopoietic pathophysiology in the elderly. To …

To investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem
cells during aging, we have conducted a comprehensive integrated genomic analysis of …

In this review we explore the importance of epigenetics as a contributing factor for aging
adult stem cells. We summarize the latest findings of epigenetic factors deregulated as adult …

Aging is invariably associated with alterations of the hematopoietic stem cell (HSC)
compartment, including loss of functional capacity, altered clonal composition, and changes …

Aging leads to functional decline of the hematopoietic system, manifested by an increased
incidence of hematological disease in the elderly. Deterioration of hematopoietic integrity …

Background The decline of hematopoietic stem cell (HSC) function upon aging contributes
to aging-associated immune remodeling and leukemia pathogenesis. Aged HSCs show …

Age-related defects in stem cells can limit proper tissue maintenance and hence contribute
to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to …

DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and
in the commitment to the lymphoid or myeloid lineages. Using purified CD34+ hematopoietic …

Aging is associated with reduced organ function and increased disease incidence.
Hematopoietic stem cell (HSC) aging driven by both cell intrinsic and extrinsic factors is …