Evidence of extensive cellular immune response after SARS-CoV-2 vaccination in ocrelizumab-treated patients with multiple sclerosis

M Pompsch, N Fisenkci, PA Horn, M Kraemer… - … Research and Practice, 2021 - Springer
Background Patients with multiple sclerosis receiving ocrelizumab-treatment are in
desperate need of a protection against SARS-CoV-2 infection. Methods In this study …

Preliminary evidence of blunted humoral response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients treated with ocrelizumab

A Gallo, R Capuano, G Donnarumma, A Bisecco… - Neurological …, 2021 - Springer
Objectives Several concerns regard the immunogenicity of SARS-CoV-2 vaccines in people
with multiple sclerosis (pwMS), since the majority of them is treated with immunomodulating …

[HTML][HTML] Humoral and T-cell responses to SARS-CoV-2 vaccination in multiple sclerosis patients treated with ocrelizumab

JD Katz, AJ Bouley, RM Jungquist, EA Douglas… - Multiple Sclerosis and …, 2022 - Elsevier
Background The COVID-19 epidemic raises important questions about the efficacy of
vaccines for people treated with ocrelizumab, an anti-CD20 therapy. Ocrelizumab has been …

Immune response to SARS-CoV-2 vaccination in relation to peripheral immune cell profiles among patients with multiple sclerosis receiving ocrelizumab

S Räuber, M Korsen, N Huntemann, L Rolfes… - Journal of Neurology …, 2022 - jnnp.bmj.com
Background Vaccination has proven to be effective in preventing SARS-CoV-2 transmission
and severe disease courses. However, immunocompromised patients have not been …

Humoral and T-cell response to SARS-CoV-2 vaccination in patients with multiple sclerosis treated with ocrelizumab

L Brill, A Rechtman, O Zveik, N Haham… - JAMA …, 2021 - jamanetwork.com
Importance B-cell–depleting therapies may affect the development of a protective immune
response following vaccination. Understanding the ability to develop vaccine-specific …

Longitudinal T-cell responses after a third SARS-CoV-2 vaccination in patients with multiple sclerosis on ocrelizumab or fingolimod

V Palomares Cabeza, LYL Kummer… - Neurology …, 2022 - AAN Enterprises
Objectives To evaluate whether a third vaccination shows an added effect on severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell responses in patients with multiple …

Longitudinal study of immunity to SARS‐CoV2 in ocrelizumab‐treated MS patients up to 2 years after COVID‐19 vaccination

I Kister, R Curtin, AL Piquet, T Borko… - Annals of Clinical …, 2024 - Wiley Online Library
Objectives (1) To plot the trajectory of humoral and cellular immune responses to the primary
(two‐dose) COVID‐19 mRNA series and the third/booster dose in B‐cell‐depleted multiple …

[HTML][HTML] Longitudinal humoral response after SARS-CoV-2 vaccination in ocrelizumab treated MS patients: to wait and repopulate?

ZLE van Kempen, L Wieske, EW Stalman… - Multiple sclerosis and …, 2022 - Elsevier
Objective The objective of this study was to measure humoral responses after SARS-CoV-2
vaccination in MS patients treated with ocrelizumab (OCR) compared to MS patients without …

Immune monitoring of SARS-CoV-2-specific T cell and B cell responses in patients with multiple sclerosis treated with ocrelizumab

E Groß-Albenhausen, A Weier, M Velten… - Frontiers in …, 2023 - frontiersin.org
Introduction Since the development of the coronavirus disease (COVID-19) pandemic
caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), there has …

Antibody response elicited by the SARS‐CoV‐2 vaccine booster in patients with multiple sclerosis: Who gains from it?

I Schiavetti, M Inglese, J Frau… - European Journal of …, 2023 - Wiley Online Library
Background and purpose Although two doses of COVID‐19 vaccine elicited a protective
humoral response in most persons with multiple sclerosis (pwMS), a significant group of …