Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm

M Shen, J Lee, R Basu, SSVP Sakamuri… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Aortic aneurysm, focal dilation of the aorta, results from impaired integrity of
aortic extracellular matrix (ECM). Matrix metalloproteinases (MMPs) are traditionally known …

Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm

KD Rizas, N Ippagunta, MD Tilson III - Cardiology in review, 2009 - journals.lww.com
Abdominal aortic aneurysm is a multifactorial disease with genetic risk factors and an
immunologic component. Immune cells, including macrophages, neutrophils, mast cells, B …

Recent advances in pharmacotherapy development for abdominal aortic aneurysm

K Yoshimura, H Aoki - International Journal of Vascular …, 2012 - Wiley Online Library
Abdominal aortic aneurysm (AAA) is a common disease causing segmental expansion and
rupture of the aorta with a high mortality rate. The lack of nonsurgical treatment represents a …

The pathophysiologic basis of abdominal aortic aneurysm progression: a critical appraisal

JHN Lindeman - Expert review of cardiovascular therapy, 2015 - Taylor & Francis
An aneurysm of the abdominal aorta is a common pathology and a major cause of sudden
death in the elderly. Currently, abdominal aortic aneurysms (AAAs) can only be treated by …

Insights on aortic aneurysm and dissection: Role of the extracellular environment in vascular homeostasis

Y Wang, P Gao, F Li, J Du - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
Aortic aneurysm and dissection (AAD) is a life-threatening medical condition associated with
high morbidity and mortality rates. Important mechanisms underlying AAD are the …

Pharmacological therapy of abdominal aortic aneurysm: an update

Y Wang, Z Liu, J Ren, M Xiang - Current vascular …, 2018 - ingentaconnect.com
Background: Abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic
dilation, is associated with high mortality. AAA is characterized by inflammation, smooth …

Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease

MW Manning, LA Cassis, J Huang… - Vascular …, 2002 - journals.sagepub.com
Abdominal aortic aneurysms (AAA) have a high prevalence in aged populations and are
responsible for a large number of deaths. Despite the widespread nature of the disease …

Biology of aortic aneurysms and dissections.

JS Fernandez-Moure, D Vykoukal… - Methodist DeBakey …, 2011 - search.ebscohost.com
The biology of aortic aneurysm and dissection has evolved to where we now understand the
genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and …