Reduction of digoxin effect during the digoxin‐quinidine interaction
G Das, CE Barr, J Carlson - Clinical Pharmacology & …, 1984 - Wiley Online Library
The effects of the digoxin‐quinidine interaction on cardiac function was examined in healthy
subjects. Our results indicate that while serum digoxin levels were elevated, the improved …
subjects. Our results indicate that while serum digoxin levels were elevated, the improved …
Enhanced cardiac effect of digoxin during quinidine treatment
EB Leahey, JA Reiffel, RH Heissenbuttel… - Archives of Internal …, 1979 - jamanetwork.com
Quinidine causes an increase in the serum digoxin concentration. Three patients were
studied to determine if the increase in serum concentration is paralleled by an increase in …
studied to determine if the increase in serum concentration is paralleled by an increase in …
Quinidine-digoxin interaction: Pharmacokinetics, underlying mechanism and clinical implications
W Doering - New England Journal of Medicine, 1979 - Mass Medical Soc
Administration of quinidine with digoxin increased serum digoxin concentrations in 79
patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the …
patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the …
Further insights into digoxin-quinidine interaction: lack of correlation between serum digoxin concentration and inotropic state of the heart
PD Hirsh, HJ Weiner, RL North - The American Journal of Cardiology, 1980 - Elsevier
The digoxin-quinidine interaction was studied in nine healthy human subjects aged 26 to 31
years. A single oral dose (400 mg) of quinidine sulfate administered to subjects taking …
years. A single oral dose (400 mg) of quinidine sulfate administered to subjects taking …
Cardiac effects of treatment with quinidine and digoxin, alone and in combination
K Schenck-Gustafsson, T Jogestrand, LÅ Brodin… - The American Journal of …, 1983 - Elsevier
Systolic time intervals (QS 2-I and LVET-I) and echocardiographically determined ejection
fraction and velocity of circumferential fiber shortening were recorded in 10 healthy …
fraction and velocity of circumferential fiber shortening were recorded in 10 healthy …
Effect of quinidine on the digoxin receptor in vitro.
WJ Ball, D Tse-Eng, ET Wallick… - The Journal of …, 1981 - Am Soc Clin Investig
To investigate the basis for a clinically important digitalis-quinidine interaction that is
characterized by increases in serums digoxin concentrations when quinidine is …
characterized by increases in serums digoxin concentrations when quinidine is …
Quinidine‐digoxin interaction: Cardiac efficacy of elevated serum digoxin concentration
GG Belz, W Doering, PE Aust, M Heinz… - Clinical …, 1982 - Wiley Online Library
Cardioactivity due to elevated serum digoxin concentration (SDC) after quinidine (Q) and
digoxin (D) was evaluated in six healthy subjects by means of measurement of systolic time …
digoxin (D) was evaluated in six healthy subjects by means of measurement of systolic time …
Tissue digoxin concentrations during the quinidine-digoxin interaction
NJ Warne, EB Leahey Jr, TJ Hougen… - The American Journal of …, 1983 - Elsevier
Digoxin concentrations in serum, myocardium, 3 separate skeletal muscles, kidney, liver,
and 5 sites in the brain were measured in 26 dogs given 12-alpha 3 H-digoxin. Ten of the …
and 5 sites in the brain were measured in 26 dogs given 12-alpha 3 H-digoxin. Ten of the …
A previously unrecognized drug interaction between quinidine and digoxin
JA Reiffel, EB Leahey Jr, RE Drusin… - Clinical …, 1979 - Wiley Online Library
Following the development of digoxin radioimmunoassay, we noted that serum digoxin
concentrations appeared to rise in patients given quinidine. To further evaluate this …
concentrations appeared to rise in patients given quinidine. To further evaluate this …
Digoxin-quinidine interaction: Changes in canine tissue concentration from steady state with quinidine
JE Doherty, KD Straub, ML Murphy, N De Soyza… - The American Journal of …, 1980 - Elsevier
Tissue concentrations of tritiated digoxin in the dog are altered by simultaneous
administration of quinidine. Serum levels rise as tissue concentration decreases significantly …
administration of quinidine. Serum levels rise as tissue concentration decreases significantly …