Infection of the liver with hepatitis C virus (HCV) causes compartmentalization of CD8+
cytotoxic T cells to the site of disease. These cells are thought to be involved in viral …

Background/Aims: To examine the T-cell repertoire which is involved in the
immunopathogenesis of chronic hepatitis, we analyzed the T-cell receptor Vβ gene usage in …

Hepatitis C virus (HCV) has a high propensity for persistence. To better define the
immunologic determinants of HCV clearance and persistence, we examined the circulating …

Studies were undertaken to clarify the immunological mechanism in patients with chronic
hepatitis C compared with chronic hepatitis B. Phenotypic study by flow cytometry showed …

Background/Aims: The intrahepatic immune system is likely to play a key role in determining
the outcome of hepatitis C virus (HCV) infection. The hepatic lymphocyte repertoire is …

The role of intrahepatic lymphocytes in the control of hepatitis C virus (HCV) infection and
the pathology associated with it is not understood; most studies of the immunology of this …

Regulatory T (TR) cells consist of phenotypically and functionally distinct CD4+ and CD8+ T
cell subsets engaged both in maintaining self-tolerance and in preventing anti–non-self …

The pathogenic mechanisms that lead to chronic hepatitis C are unknown. As hepatitis C
virus (HCV) has been shown to induce T cell response, we assessed whether a particular T …

Results Acute hepatitis patients had a high proportion of CD3+ T cells with increased CD4+
CD45RA-T helper and CD8+ CD11b-cytotoxic T cells. Compared to this group, chronic …