In hepatitis C virus (HCV) infection the immune response is ineffective, leading to chronic
hepatitis and liver damage. Primed CD8 T cells are critical for antiviral immunity and subsets …

CD4+ T‐cell responses are important for the outcome of hepatitis C virus (HCV) infection.
However, the functional status of HCV‐specific CD4+ T cells in persistent infection is poorly …

T cells can be divided into two main phenotypic subpopulations–ie, the CD45RA‐positive
(2H4‐positive)“naive” subset and the CD45RO‐positive (UCHL1‐positive)“memory” subset …

This study was performed to compare the vigor and phenotype of virus-specific CD4+ and
CD8+ T-cell responses in patients with different virologic and clinical outcomes after …

The cellular immune response contributes to clearance of hepatitis C virus (HCV) and
persists for decades after recovery from infection. The immunological basis for the …

Chronic hepatitis C virus (HCV) infection is characterized by extensive infiltration of
inflammatory cells in the liver, where there is a compartmentalization of HCV-reactive T …

Chronic infection with hepatitis C virus (HCV) causes a quantitative and functional alteration
in innate and adaptative immunity. In the present work, we determined by flow-cytometry the …

Intrahepatic virus-specific CD8+ T cells are thought to be important for the control of hepatitis
C virus (HCV) infection, yet the precise kinetics for the expansion of epitope-specific T cells …

The pathogenesis and perpetuation of hepatocellular injury in hepatitis C viral infection
remains unclear. It has been proposed that a direct viropathic effect, the host immune …

This study aims to deepen the understanding of lymphocyte phenotypes related to the
course of hepatitis C virus (HCV) infection and progression of liver fibrosis in a cohort of …