Botulinum neurotoxin: a marvel of protein design
M Montal - Annual review of biochemistry, 2010 - annualreviews.org
Botulinum neurotoxin (BoNT), the causative agent of botulism, is acknowledged to be the
most poisonous protein known. BoNT proteases disable synaptic vesicle exocytosis by …
most poisonous protein known. BoNT proteases disable synaptic vesicle exocytosis by …
Engineered botulinum neurotoxins as new therapeutics
G Masuyer, JA Chaddock, KA Foster… - Annual review of …, 2014 - annualreviews.org
Botulinum neurotoxins (BoNTs) cause flaccid paralysis by inhibiting neurotransmission at
cholinergic nerve terminals. Each BoNT consists of three domains that are essential for …
cholinergic nerve terminals. Each BoNT consists of three domains that are essential for …
New insights into clostridial neurotoxin–SNARE interactions
MA Breidenbach, AT Brunger - Trends in molecular medicine, 2005 - cell.com
Botulinum neurotoxin serotype A (BoNT/A) has achieved a dichotomous status in modern
medicine; it is both a versatile treatment for several neurological disorders and a lethal …
medicine; it is both a versatile treatment for several neurological disorders and a lethal …
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists
LM Eubanks, MS Hixon, W Jin… - Proceedings of the …, 2007 - National Acad Sciences
Among the agents classified as “Category A” by the US Centers for Disease Control and
Prevention, botulinum neurotoxin (BoNT) is the most toxic protein known, with microgram …
Prevention, botulinum neurotoxin (BoNT) is the most toxic protein known, with microgram …
Botulinum neurotoxins: mechanism of action
O Rossetto, M Pirazzini, F Fabris… - Botulinum Toxin …, 2021 - Springer
Botulinum neurotoxins (BoNTs) are a growing family of bacterial protein toxins that cause
botulism, a rare but often fatal animal and human disease. They are the most potent toxins …
botulism, a rare but often fatal animal and human disease. They are the most potent toxins …
Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system
Botulinum neurotoxins (BoNTs) are the most potent natural toxins known. The effects of
BoNT serotype A (BoNT/A) can last several months, whereas the effects of BoNT serotype E …
BoNT serotype A (BoNT/A) can last several months, whereas the effects of BoNT serotype E …
Traffic of botulinum toxins A and E in excitatory and inhibitory neurons
C Verderio, C Grumelli, L Raiteri, S Coco, S Paluzzi… - Traffic, 2007 - Wiley Online Library
Botulinum neurotoxins (BoNTs), proteases specific for the SNARE proteins, are used to
study the molecular machinery supporting exocytosis and are used to treat human diseases …
study the molecular machinery supporting exocytosis and are used to treat human diseases …
Mechanism of substrate recognition by botulinum neurotoxin serotype A
S Chen, JJP Kim, JT Barbieri - Journal of biological chemistry, 2007 - ASBMB
Botulinum neurotoxins (BoNTs) are zinc proteases that cleave SNARE proteins to elicit
flaccid paralysis by inhibiting neurotransmitter-carrying vesicle fusion to the plasma …
flaccid paralysis by inhibiting neurotransmitter-carrying vesicle fusion to the plasma …
Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics
J Wang, J Meng, GW Lawrence, TH Zurawski… - Journal of Biological …, 2008 - ASBMB
Hyperexcitability disorders of cholinergically innervated muscles are treatable with
botulinum neurotoxin (BoNT) A. The seven serotypes (A–G) potently block …
botulinum neurotoxin (BoNT) A. The seven serotypes (A–G) potently block …
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Botulinum neurotoxins (BoNTs) are produced by Clostridium botulinum and cause the
neuroparalytic syndrome of botulism. With a lethal dose of 1 ng kg-1, they pose a biological …
neuroparalytic syndrome of botulism. With a lethal dose of 1 ng kg-1, they pose a biological …