[HTML][HTML] Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance

AL Poher, J Altirriba, C Veyrat-Durebex… - Frontiers in …, 2015 - frontiersin.org
Presence of brown adipose tissue (BAT), characterized by the expression of the
thermogenic uncoupling protein 1 (UCP1), has recently been described in adult humans …

Recruitment of brown adipose tissue as a therapy for obesity-associated diseases

O Boss, SR Farmer - Frontiers in endocrinology, 2012 - frontiersin.org
Brown adipose tissue (BAT) has been recognized for more than 20 years to play a key role
in cold-induced non-shivering thermogenesis (CIT, NST), and body weight homeostasis in …

Uncoupling protein 1 and the capacity for nonshivering thermogenesis are components of the glucose homeostatic system

SF Maurer, T Fromme, S Mocek… - American Journal …, 2020 - journals.physiology.org
Uncoupling protein 1 (Ucp1) provides nonshivering thermogenesis (NST) fueled by the
dissipation of energy from macronutrients in brown and brite adipocytes. The availability of …

Uncoupling protein 1 expression and high-fat diets

T Fromme, M Klingenspor - American Journal of Physiology …, 2011 - journals.physiology.org
Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled
nonshivering thermogenesis in brown adipocytes. This process combusts stored and …

Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes

Y Li, T Fromme, S Schweizer, T Schöttl… - EMBO …, 2014 - embopress.org
Thermogenesis in brown adipocytes, conferred by mitochondrial uncoupling protein 1 (UCP
1), is receiving great attention because metabolically active brown adipose tissue may …

Mechanisms underlying UCP1 dependent and independent adipocyte thermogenesis

SH Chang, NJ Song, JH Choi, UJ Yun… - Obesity …, 2019 - Wiley Online Library
The growing focus on brown adipocytes has spurred an interest in their potential benefits for
metabolic diseases. Brown and beige (or brite) adipocytes express high levels of uncoupling …

[HTML][HTML] Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

J Oeckl, P Janovska, K Adamcova, K Bardova… - Molecular …, 2022 - Elsevier
Objective Classical ATP-independent non-shivering thermogenesis enabled by uncoupling
protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in …

Thermogenic activity of UCP1 in human white fat-derived beige adipocytes

S Bartesaghi, S Hallen, L Huang… - Molecular …, 2015 - academic.oup.com
Heat-producing beige/brite (brown-in-white) adipocytes in white adipose tissue have the
potential to suppress metabolic disease in mice and hold great promise for the treatment of …

Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice

Y Okamatsu-Ogura, K Fukano, A Tsubota, A Uozumi… - PloS one, 2013 - journals.plos.org
Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of
white adipose tissue in mice. Despite their morphological similarities to brown adipocytes …

In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain

IHN Luijten, HM Feldmann… - American Journal …, 2019 - journals.physiology.org
The attractive tenet that recruitment and activation of brown adipose tissue (BAT) and
uncoupling protein 1 (UCP1) could counteract the development of obesity and its …