A tissue checkpoint regulates type 2 immunity
Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are
defined by their similar effector cytokines, which together mediate the features of allergic …
defined by their similar effector cytokines, which together mediate the features of allergic …
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2–dominated inflammatory response
MG Chiaramonte, DD Donaldson… - The Journal of …, 1999 - Am Soc Clin Investig
In schistosomiasis, chronic parasite egg–induced granuloma formation can lead to tissue
destruction and fibrosis, which causes much of the morbidity and mortality associated with …
destruction and fibrosis, which causes much of the morbidity and mortality associated with …
[HTML][HTML] Role of IL-6 in the commitment of T cell subsets
T Korn, M Hiltensperger - Cytokine, 2021 - Elsevier
IL-6 gained much attention with the discovery that this cytokine is a non-redundant
differentiation factor for Th17 cells and T follicular helper cells. Adaptive immune responses …
differentiation factor for Th17 cells and T follicular helper cells. Adaptive immune responses …
The role of IL-6 in skin fibrosis and cutaneous wound healing
BZ Johnson, AW Stevenson, CM Prêle, MW Fear… - Biomedicines, 2020 - mdpi.com
The timely resolution of wound healing is critical for restoring the skin as a protective barrier.
The switch from a proinflammatory to a reparative microenvironment must be tightly …
The switch from a proinflammatory to a reparative microenvironment must be tightly …
[HTML][HTML] Reduced Il17a expression distinguishes a Ly6cloMHCIIhi macrophage population promoting wound healing
Macrophages are the main components of inflammation during skin wound healing. They
are critical in wound closure and in excessive inflammation, resulting in defective healing …
are critical in wound closure and in excessive inflammation, resulting in defective healing …
The innate immune system in acute and chronic wounds
AS MacLeod, JN Mansbridge - Advances in wound care, 2016 - liebertpub.com
Significance: This review article provides an overview of the critical roles of the innate
immune system to wound healing. It explores aspects of dysregulation of individual innate …
immune system to wound healing. It explores aspects of dysregulation of individual innate …
Fibrosis related inflammatory mediators: role of the IL‐10 cytokine family
Importance of chronic fibroproliferative diseases (FDs) including pulmonary fibrosis, chronic
kidney diseases, inflammatory bowel disease, and cardiovascular or liver fibrosis is rapidly …
kidney diseases, inflammatory bowel disease, and cardiovascular or liver fibrosis is rapidly …
Interleukin-6, its role in fibrosing conditions
Interleukin-6 is a classic pro-inflammatory cytokine needed to mount an effective immune
response. It is secreted by a wide array of cell types, however, its target cells are more …
response. It is secreted by a wide array of cell types, however, its target cells are more …
Macrophage and innate lymphoid cell interplay in the genesis of fibrosis
E Hams, R Bermingham, PG Fallon - Frontiers in immunology, 2015 - frontiersin.org
Fibrosis is a characteristic pathological feature of an array of chronic diseases, where
development of fibrosis in tissue can lead to marked alterations in the architecture of the …
development of fibrosis in tissue can lead to marked alterations in the architecture of the …
Coordination of immune-stroma crosstalk by IL-6 family cytokines
NR West - Frontiers in immunology, 2019 - frontiersin.org
Stromal cells are a subject of rapidly growing immunological interest based on their ability to
influence virtually all aspects of innate and adaptive immunity. Present in every bodily tissue …
influence virtually all aspects of innate and adaptive immunity. Present in every bodily tissue …