Glucagon‐like peptide‐1 (GLP‐1) receptor agonists and their cardiovascular benefits—The role of the GLP‐1 receptor

J Helmstädter, K Keppeler, L Küster… - British journal of …, 2022 - Wiley Online Library
Cardiovascular outcome trials revealed cardiovascular benefits for type 2 diabetes mellitus
patients when treated with long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonists …

Glucagon‐like peptide‐1 receptor agonists and cardiovascular events: a meta‐analysis of randomized clinical trials

M Monami, F Cremasco, C Lamanna… - Journal of Diabetes …, 2011 - Wiley Online Library
Objective. Data from randomized clinical trials with metabolic outcomes can be used to
address concerns about potential issues of cardiovascular safety for newer drugs for type 2 …

Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action

JR Ussher, DJ Drucker - Nature Reviews Cardiology, 2023 - nature.com
Type 2 diabetes mellitus (T2DM) and obesity are metabolic disorders characterized by
excess cardiovascular risk. Glucagon-like peptide 1 (GLP1) receptor (GLP1R) agonists …

Cardiovascular effects of glucagon-like peptide 1 receptor agonists: from mechanistic studies in humans to clinical outcomes

VD Heuvelman, DH Van Raalte… - Cardiovascular …, 2020 - academic.oup.com
Type 2 diabetes mellitus (T2DM) is currently one of the most prevalent diseases, with as
many as 415 million patients worldwide. T2DM is characterized by elevated blood glucose …

Impact of GLP-1 and GLP-1 receptor agonists on cardiovascular risk factors in type 2 diabetes

D Verge, X López - Current Diabetes Reviews, 2010 - ingentaconnect.com
Type 2 diabetes (T2D) is associated with increased cardiovascular disease and mortality.
Most diabetes treatments have not proven to reduce this risk and may be associated with …

[HTML][HTML] Cardiovascular effects of glucagon-like peptide-1 receptor agonists

YM Kang, CH Jung - Endocrinology and Metabolism, 2016 - ncbi.nlm.nih.gov
Abstract Glucagon-like peptide-1 (GLP-1) is a member of the proglucagon incretin family,
and GLP-1 receptor agonists (RAs) have been introduced as a new class of antidiabetic …

[HTML][HTML] GLP-1 receptor agonists and cardiovascular disease: a meta-analysis of recent cardiac outcome trials

X Jia, M Alam, Y Ye, M Bajaj, Y Birnbaum - Cardiovascular drugs and …, 2018 - Springer
Purpose The aim of this study is to examine the cardioprotective properties of Glucagon-like
peptide-1 receptor agonist, a class of antihyperglycemic therapy, via meta-analysis of four …

Endogenous glucagon‐like peptide (GLP)‐1 as alternative for GLP‐1 receptor agonists: Could this work and how?

MM Smits, JJ Holst - Diabetes/metabolism research and …, 2023 - Wiley Online Library
In recent years, we have witnessed the many beneficial effects of glucagon‐like peptide
(GLP)‐1 receptor agonists, including the reduction in cardiovascular risk in patients with type …

Metabolic responses and benefits of glucagon‐like peptide‐1 (GLP‐1) receptor ligands

N Tanday, PR Flatt, N Irwin - British Journal of Pharmacology, 2022 - Wiley Online Library
Glucagon‐like peptide‐1 (GLP‐1) is an incretin hormone that has undergone a revolutionary
turnaround from discovery to clinically approved therapeutic. Rapid progress in drug design …

Emerging cardiovascular actions of the incretin hormone glucagon‐like peptide‐1: potential therapeutic benefits beyond glycaemic control?

DJ Grieve, RS Cassidy… - British journal of …, 2009 - Wiley Online Library
Glucagon‐like peptide‐1 (GLP‐1) is an incretin hormone secreted by the small intestine in
response to nutrient ingestion. It has wide‐ranging effects on glucose metabolism, including …