[HTML] nih.gov

Nicotine metabolite ratio (3-hydroxycotinine/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation

JA Tanner, M Novalen, P Jatlow, MA Huestis… - … Biomarkers & Prevention, 2015 - AACR
Background: The highly genetically variable enzyme CYP2A6 metabolizes nicotine to
cotinine (COT) and COT to trans-3′-hydroxycotinine (3HC). The nicotine metabolite ratio …
被引用次数：77 相关文章 所有 14 个版本
[HTML] nih.gov

Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers

MJ Chenoweth, M Novalen, LW Hawk Jr… - … Biomarkers & Prevention, 2014 - AACR
Background: The ratio of 3′ hydroxycotinine to cotinine, or nicotine metabolite ratio (NMR),
is strongly associated with CYP2A6 genotype, CYP2A6-mediated nicotine and cotinine …
被引用次数：125 相关文章 所有 13 个版本
[HTML] nih.gov

Reproducibility of the nicotine metabolite ratio in cigarette smokers

G St. Helen, M Novalen, DF Heitjan, D Dempsey… - … , biomarkers & prevention, 2012 - AACR
Background: The nicotine metabolite ratio (NMR or 3-hydroxycotinine/cotinine) has been
used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze …
被引用次数：122 相关文章 所有 9 个版本
[HTML] nih.gov

Stability of the Nicotine Metabolite Ratio in ad Libitum and Reducing Smokers

ME Mooney, Z Li, SE Murphy, PR Pentel, C Le… - … Biomarkers & Prevention, 2008 - AACR
Background: The ratio of two nicotine metabolites, cotinine and trans-3′-hydroxycotinine (3-
HC), has been validated as a method of phenotyping the activity of the liver enzyme …
被引用次数：58 相关文章 所有 9 个版本
[HTML] nih.gov

A comparison of direct and indirect analytical approaches to measuring total nicotine equivalents in urine

T Taghavi, M Novalen, C Lerman, TP George… - … Biomarkers & Prevention, 2018 - AACR
Background: Total nicotine equivalents (TNE), the sum of nicotine and metabolites in urine,
is a valuable tool for evaluating nicotine exposure. Most methods for measuring TNE involve …
被引用次数：18 相关文章 所有 7 个版本
[HTML] nih.gov

Estimation of nicotine dose after low-level exposure using plasma and urine nicotine metabolites

NL Benowitz, KM Dains, D Dempsey, L Yu… - … , biomarkers & prevention, 2010 - AACR
Background: We sought to determine the optimal plasma and urine nicotine metabolites,
alone or in combination, to estimate the systemic dose of nicotine after low-level exposure …
被引用次数：61 相关文章 所有 11 个版本
[PDF] academia.edu

CYP2A6 Genotype, Phenotype, and the Use of Nicotine Metabolites as Biomarkers during Ad libitum Smoking

V Malaiyandi, SD Goodz, EM Sellers… - … Biomarkers & Prevention, 2006 - AACR
CYP2A6 inactivates nicotine to cotinine and cotinine to 3-hydroxycotinine. We investigated
which of plasma nicotine and metabolites were most related to CYP2A6 genotype and …
被引用次数：88 相关文章 所有 12 个版本
[HTML] nih.gov

Collaborative method performance study of the measurement of nicotine, its metabolites, and total nicotine equivalents in human urine

L Wang, JT Bernert, NL Benowitz, J Feng… - … Biomarkers & Prevention, 2018 - AACR
Background: Biomarkers of tobacco exposure have a central role in studies of tobacco use
and nicotine intake. The most significant exposure markers are nicotine itself and its …
被引用次数：18 相关文章 所有 10 个版本
[HTML] nih.gov

The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex

AZX Zhu, CC Renner, DK Hatsukami, GE Swan… - … , biomarkers & prevention, 2013 - AACR
Background: Cotinine, a nicotine metabolite, is a biomarker of tobacco, nicotine, and
carcinogen exposure. However, a given cotinine level may not represent the same tobacco …
被引用次数：97 相关文章 所有 15 个版本
[HTML] nih.gov

Urine metabolites for estimating daily intake of nicotine from cigarette smoking

NL Benowitz, G St. Helen, N Nardone… - Nicotine and …, 2020 - academic.oup.com
Introduction Accurate measurement of nicotine exposure from cigarette smoke is important
in studying disease risk and level of dependence. Urine total nicotine equivalents, the molar …
被引用次数：34 相关文章 所有 9 个版本