Synthesis, antimicrobial activity, pharmacophore modeling and molecular docking studies of new pyrazole-dimedone hybrid architectures
Background Design and synthesis of pyrazole-dimedone derivatives were described by one-
pot multicomponent reaction as new antimicrobial agents. These new molecular framework …
pot multicomponent reaction as new antimicrobial agents. These new molecular framework …
New azoles with potent antifungal activity: design, synthesis and molecular docking
In response to the urgent need for novel antifungal agents with improved activity and
broader spectrum, computer modeling was used to rational design novel antifungal azoles …
broader spectrum, computer modeling was used to rational design novel antifungal azoles …
Design, synthesis and mechanistic study of new 1, 2, 4-triazole derivatives as antimicrobial agents
NH Amin, MT El-Saadi, AA Ibrahim… - Bioorganic …, 2021 - Elsevier
Abstract Novel 5-amino-1, 2, 4-triazole derivatives and their cyclized 1, 2, 4-triazolo [1, 5-a]
pyrimidine analogues were designed, synthesized and evaluated for their antimicrobial …
pyrimidine analogues were designed, synthesized and evaluated for their antimicrobial …
Synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to P45014DM by molecular docking and MM …
D Zampieri, MG Mamolo, L Vio, E Banfi… - Bioorganic & Medicinal …, 2007 - Elsevier
New bis-imidazole derivatives have been synthesized and their antifungal and
antimycobacterial activity was determined. Almost all compounds exhibited a moderate to …
antimycobacterial activity was determined. Almost all compounds exhibited a moderate to …
Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents
Abstract Twenty compounds of pyrazolo [1, 5-a] pyrimidines 14a–j and pyrazole derivatives
as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole …
as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole …
Synthesis, in silico prediction and in vitro evaluation of antimicrobial activity, dft calculation and theoretical investigation of novel xanthines and uracil containing …
S El-Kalyoubi, F Agili, WA Zordok… - International Journal of …, 2021 - mdpi.com
Novel xanthine and imidazolone derivatives were synthesized based on oxazolone
derivatives 2a-c as a key intermediate. The corresponding xanthine 3-5 and imidazolone …
derivatives 2a-c as a key intermediate. The corresponding xanthine 3-5 and imidazolone …
Design, synthesis, antimicrobial activity and computational studies of novel azo linked substituted benzimidazole, benzoxazole and benzothiazole derivatives
VR Mishra, CW Ghanavatkar, SN Mali… - … biology and chemistry, 2019 - Elsevier
Novel azo linked substituted benzimidazole, benzoxazole, and benzothiazole were
synthesized by diazo coupling and characterized by 1 H NMR, elemental analysis, FTIR and …
synthesized by diazo coupling and characterized by 1 H NMR, elemental analysis, FTIR and …
Synthesis, identification, computer-aided docking studies, and ADMET prediction of novel benzimidazo-1, 2, 3-triazole based molecules as potential antimicrobial …
2-azido-1 H-benzo [d] imidazole derivatives 1a, b were reacted with a β-ketoester such as
acetylacetone in the presence of sodium ethoxide to obtain the desired molecules 2a, b. The …
acetylacetone in the presence of sodium ethoxide to obtain the desired molecules 2a, b. The …
Computational studies of a series of 2-substituted phenyl-2-oxo-, 2-hydroxyl-and 2-acylloxyethylsulfonamides as potent anti-fungal agents
Botrytis Cinerea is a plant pathogen that affect a large number of plant species like
tomatoes, Lettuce, Grapes, and Strawberries among others. Sulfonamides are widely used …
tomatoes, Lettuce, Grapes, and Strawberries among others. Sulfonamides are widely used …
Antimicrobial evaluation and docking study of some new substituted benzimidazole-2yl derivatives
Benzimidazoles incorporated biologically active heterocycles such as quinoline, triazine-3-
thione, thiazole and thiadiazole, were synthesized utilizing 2-acetylbenzimidazole as a …
thione, thiazole and thiadiazole, were synthesized utilizing 2-acetylbenzimidazole as a …