Synthesis, antimicrobial activity and advances in structure-activity relationships (SARs) of novel tri-substituted thiazole derivatives
Trisubstituted thiazoles were synthesized and studied for their antimicrobial activity and
supported by theoretical calculations. In addition, MIC, MBC and MFC were also tested …
supported by theoretical calculations. In addition, MIC, MBC and MFC were also tested …
[HTML][HTML] Synthesis and antifungal potential of some novel benzimidazole-1, 3, 4-oxadiazole compounds
AÇ Karaburun, B Kaya Çavuşoğlu, U Acar Çevik… - Molecules, 2019 - mdpi.com
Discovery of novel anticandidal agents with clarified mechanisms of action, could be a
rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to …
rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to …
Design, synthesis, α-glucosidase inhibitory activity, molecular docking and QSAR studies of benzimidazole derivatives
L Dinparast, H Valizadeh, MB Bahadori… - Journal of Molecular …, 2016 - Elsevier
In this study the green, one-pot, solvent-free and selective synthesis of benzimidazole
derivatives is reported. The reactions were catalyzed by ZnO/MgO containing ZnO …
derivatives is reported. The reactions were catalyzed by ZnO/MgO containing ZnO …
[HTML][HTML] In-silico molecular docking and ADME/pharmacokinetic prediction studies of some novel carboxamide derivatives as anti-tubercular agents
M Abdullahi, SE Adeniji - Chemistry Africa, 2020 - Springer
Molecular docking simulation of thirty-five (35) molecules of N-(2-phenoxy) ethyl imidazo [1,
2-a] pyridine-3-carboxamide (IPA) with Mycobacterium tuberculosis target (DNA gyrase) was …
2-a] pyridine-3-carboxamide (IPA) with Mycobacterium tuberculosis target (DNA gyrase) was …
Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation
Y An, Y Dong, M Liu, J Han, L Zhao, B Sun - European Journal of Medicinal …, 2021 - Elsevier
Fungal infections have become a serious medical problem due to the high infection rate and
the frequent emergence of drug resistance. Squalene epoxidase (SE) and 14α-demethylase …
the frequent emergence of drug resistance. Squalene epoxidase (SE) and 14α-demethylase …
Design, synthesis, molecular docking and DFT computational insight on the structure of Piperazine sulfynol derivatives as a new antibacterial contender against …
HSN Prasad, AP Ananda, TN Lohith… - Journal of Molecular …, 2022 - Elsevier
In this investigation, a series of piperazine sulfynol derivatives 5 (al) were synthesized and
amply characterized by various spectral techniques viz, LC-MS, 1 H NMR, 13 C NMR, and …
amply characterized by various spectral techniques viz, LC-MS, 1 H NMR, 13 C NMR, and …
[HTML][HTML] In-silico molecular design of heterocyclic benzimidazole scaffolds as prospective anticancer agents
Benzimidazole is a valuable pharmacophore in the field of medicinal chemistry and exhibit
wide spectrum of biological activity. Molecular docking technique is routinely used in …
wide spectrum of biological activity. Molecular docking technique is routinely used in …
Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety
In this study 12 novel benzimidazole compounds bearing hydrazone moiety were
synthesized in order to investigate their possible antibacterial and antifungal activity …
synthesized in order to investigate their possible antibacterial and antifungal activity …
Synthesis, biological screening and in silico studies of new N-phenyl-4-(1, 3-diaryl-1H-pyrazol-4-yl) thiazol-2-amine derivatives as potential antifungal and …
Y Nandurkar, MR Bhoye, D Maliwal… - European Journal of …, 2023 - Elsevier
A new series of N-aryl-4-(1, 3-diaryl-1H-pyrazol-4-yl) thiazol-2-amine,(8a-x) have been
synthesized by a cyclo-condensation reaction of 2-bromo-1-(1, 3-diphenyl-1H-pyrazol-4-yl) …
synthesized by a cyclo-condensation reaction of 2-bromo-1-(1, 3-diphenyl-1H-pyrazol-4-yl) …
Homology model, molecular dynamics simulation and novel pyrazole analogs design of Candida albicans CYP450 lanosterol 14 α-demethylase, a target enzyme for …
Candida albicans infections and their resistance to clinically approved azole drugs are
major concerns for human. The azole antifungal drugs inhibit the ergosterol synthesis by …
major concerns for human. The azole antifungal drugs inhibit the ergosterol synthesis by …