Early detection and prognosis evaluation for hepatocellular carcinoma by circulating tumour DNA methylation: A multicentre cohort study

DZ Guo, A Huang, YC Wang, S Zhou… - Clinical and …, 2024 - Wiley Online Library
Background Early diagnosis of hepatocellular carcinoma (HCC) can significantly improve
patient survival. We aimed to develop a blood‐based assay to aid in the diagnosis, detection …

[PDF][PDF] Hepatocellular carcinoma detection by plasma methylated DNA: discovery, phase I pilot, and phase II clinical validation

JB Kisiel, BA Dukek, R VSR Kanipakam, HM Ghoz… - …, 2019 - Wiley Online Library
Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive
surveillance tools are needed. We aimed to identify and validate methylated DNA markers …

621P Effective identification of primary liver cancer from cirrhosis or chronic hepatitis virus infection using eight methylated plasma DNA markers: Marker discovery …

T Yang, N Wang, X Zhu, M Wang, L Yao… - Annals of …, 2023 - annalsofoncology.org
Background Early detection of primary liver cancer (PLC) in patients with liver cirrhosis (LC)
or chronic hepatitis virus infection (CHVI) improves survival. The urgent need is convenient …

Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma

B Luo, F Ma, H Liu, J Hu, L Rao, C Liu, Y Jiang… - BMC medicine, 2022 - Springer
Background Aberrant DNA methylation may offer opportunities in revolutionizing cancer
screening and diagnosis. We sought to identify a non-invasive DNA methylation-based …

Circulating DNA methylation profile improves the accuracy of serum biomarkers for the detection of nonmetastatic hepatocellular carcinoma

TH Phan, VT Chi Nguyen, TT Thi Pham… - Future …, 2022 - Taylor & Francis
Aim: This study exploited hepatocellular carcinoma (HCC)-specific circulating DNA
methylation profiles to improve the accuracy of a current screening assay for HCC patients in …

[HTML][HTML] DNA methylation markers in the detection of hepatocellular carcinoma

S Fu, JD Debes, A Boonstra - European Journal of Cancer, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a
poor prognosis. Epigenetic modification has been shown to be deregulated during HCC …

DNA methylation: potential biomarker in Hepatocellular Carcinoma

WC Mah, CGL Lee - Biomarker research, 2014 - Springer
Hepatocellular Carcinoma (HCC) is one of the most common cancers in the world and it is
often associated with poor prognosis. Liver transplantation and resection are two currently …

Discovery and clinical validation of cost-effective noninvasive early detection of hepatocellular carcinoma (HCC) through circulating tumor DNA (ctDNA) methylation …

XR Yang, R Liu, J Zhou, J Fan, DZ Guo, A Huang… - 2022 - ascopubs.org
4103 Background: Hepatocellular carcinoma (HCC) is one of the most common and lethal
cancers worldwide, especially in Asian counties. Patients can be treated more effectively if …

Hypermethylation of DNA methylation markers in non-cirrhotic hepatocellular carcinoma

S Fu, T Deger, RG Boers, JB Boers, M Doukas… - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) remains a significant cause of cancer-
related deaths worldwide. Although most HCC cases have a background of cirrhosis, up to …

DNA methylation fingerprint of hepatocellular carcinoma from tissue and liquid biopsies

E Gonçalves, M Gonçalves-Reis, JB Pereira-Leal… - Scientific Reports, 2022 - nature.com
Hepatocellular carcinoma (HCC) is amongst the cancers with highest mortality rates and is
the most common malignancy of the liver. Early detection is vital to provide the best …