Early detection and prognosis evaluation for hepatocellular carcinoma by circulating tumour DNA methylation: A multicentre cohort study
DZ Guo, A Huang, YC Wang, S Zhou… - Clinical and …, 2024 - Wiley Online Library
Background Early diagnosis of hepatocellular carcinoma (HCC) can significantly improve
patient survival. We aimed to develop a blood‐based assay to aid in the diagnosis, detection …
patient survival. We aimed to develop a blood‐based assay to aid in the diagnosis, detection …
[PDF][PDF] Hepatocellular carcinoma detection by plasma methylated DNA: discovery, phase I pilot, and phase II clinical validation
Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive
surveillance tools are needed. We aimed to identify and validate methylated DNA markers …
surveillance tools are needed. We aimed to identify and validate methylated DNA markers …
621P Effective identification of primary liver cancer from cirrhosis or chronic hepatitis virus infection using eight methylated plasma DNA markers: Marker discovery …
T Yang, N Wang, X Zhu, M Wang, L Yao… - Annals of …, 2023 - annalsofoncology.org
Background Early detection of primary liver cancer (PLC) in patients with liver cirrhosis (LC)
or chronic hepatitis virus infection (CHVI) improves survival. The urgent need is convenient …
or chronic hepatitis virus infection (CHVI) improves survival. The urgent need is convenient …
Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma
B Luo, F Ma, H Liu, J Hu, L Rao, C Liu, Y Jiang… - BMC medicine, 2022 - Springer
Background Aberrant DNA methylation may offer opportunities in revolutionizing cancer
screening and diagnosis. We sought to identify a non-invasive DNA methylation-based …
screening and diagnosis. We sought to identify a non-invasive DNA methylation-based …
Circulating DNA methylation profile improves the accuracy of serum biomarkers for the detection of nonmetastatic hepatocellular carcinoma
TH Phan, VT Chi Nguyen, TT Thi Pham… - Future …, 2022 - Taylor & Francis
Aim: This study exploited hepatocellular carcinoma (HCC)-specific circulating DNA
methylation profiles to improve the accuracy of a current screening assay for HCC patients in …
methylation profiles to improve the accuracy of a current screening assay for HCC patients in …
[HTML][HTML] DNA methylation markers in the detection of hepatocellular carcinoma
S Fu, JD Debes, A Boonstra - European Journal of Cancer, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a
poor prognosis. Epigenetic modification has been shown to be deregulated during HCC …
poor prognosis. Epigenetic modification has been shown to be deregulated during HCC …
DNA methylation: potential biomarker in Hepatocellular Carcinoma
Hepatocellular Carcinoma (HCC) is one of the most common cancers in the world and it is
often associated with poor prognosis. Liver transplantation and resection are two currently …
often associated with poor prognosis. Liver transplantation and resection are two currently …
Discovery and clinical validation of cost-effective noninvasive early detection of hepatocellular carcinoma (HCC) through circulating tumor DNA (ctDNA) methylation …
XR Yang, R Liu, J Zhou, J Fan, DZ Guo, A Huang… - 2022 - ascopubs.org
4103 Background: Hepatocellular carcinoma (HCC) is one of the most common and lethal
cancers worldwide, especially in Asian counties. Patients can be treated more effectively if …
cancers worldwide, especially in Asian counties. Patients can be treated more effectively if …
Hypermethylation of DNA methylation markers in non-cirrhotic hepatocellular carcinoma
S Fu, T Deger, RG Boers, JB Boers, M Doukas… - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) remains a significant cause of cancer-
related deaths worldwide. Although most HCC cases have a background of cirrhosis, up to …
related deaths worldwide. Although most HCC cases have a background of cirrhosis, up to …
DNA methylation fingerprint of hepatocellular carcinoma from tissue and liquid biopsies
E Gonçalves, M Gonçalves-Reis, JB Pereira-Leal… - Scientific Reports, 2022 - nature.com
Hepatocellular carcinoma (HCC) is amongst the cancers with highest mortality rates and is
the most common malignancy of the liver. Early detection is vital to provide the best …
the most common malignancy of the liver. Early detection is vital to provide the best …
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