Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino …

Epigenetic phenomena are heritable changes to gene expression that occur without
changes to the DNA sequence and that include posttranslational modifications (PTMs) to the …

The nucleosome surface is decorated with an array of enzyme-catalysed modifications on
histone tails. These modifications have well-defined roles in a variety of ongoing chromatin …

Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …

Background The phenotype of an organism is an outcome of both its genotype, encoding the
primary sequence of proteins, and the developmental orchestration of gene expression. The …

The eukaryotic DNA is wrapped around histone octamers, which consist of four different
histones, H2A, H2B, H3 and H4. The N-terminal tail of each histone is post-transcriptionally …

Most multi-cellular organisms adopt a specific gene expression pattern during cellular
differentiation. Once established, this pattern is frequently maintained over several cell …