Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both
hormones act centrally, regulating food intake and adiposity in humans. Leptin has several …

Leptin is an adipocyte-derived hormone that primarily acts in the hypothalamus and plays a
key role in the regulation of food intake, body weight, energy expenditure and …

The fat‐derived hormone, leptin, is well known to regulate body weight. However, there is
now substantial evidence that leptin also plays a primary role in the regulation of glucose …

Leptin was discovered in 1994 (20 years ago). In addition to having well-characterized
effects on the regulation of energy homeostasis, leptin clearly also plays a major role in …

Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …

Since the discovery of leptin in 1994, we now have a better understanding of the cellular and
molecular mechanisms underlying its biological effects. In addition to its established anti …

Obesity and diabetes mellitus are great public health concerns throughout the world
because of their increasing incidence and prevalence. Leptin, the adipocyte hormone, is …

Diabetes is a major worldwide problem. Despite some progress in the development of new
antidiabetic agents, the ability to maintain tight glycemic control in order to prevent renal …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Leptin has a crucial role in regulating food intake and maintaining metabolic homeostasis.
Although little is known about the process of leptin secretion, insulin, which has an important …