Cytokines are critical coordinators of the immune response necessary for resolving bacterial
and viral assaults on the immune system. In particular, the IL-12 family of cytokines are key …

Introduction Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major
players in the immune response to foreign pathogens. In addition, the pathogeneses of a …

Understanding the factors that influence T helper 1 (TH1)-and TH2-cell responses has been
one of the main focuses of immunology for almost 20 years. Whereas the central role of …

Long-term resistance to many infections depends on the innate ability of the immune system
to coordinate the development of antigen-specific adaptive responses. Deficiencies in these …

Abstract Cytokines IL-17 and IL-22 play pivotal roles in host defense against microbes and
in the development of chronic inflammatory diseases. These cytokines are produced by cells …

Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in
the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper …

The functional characterization and subsequent purification of T cell growth factor/interleukin
(IL)-2 in the early 1980s established this secreted protein as a key mediator of immune cell …

Cytokines play critical roles in regulating all aspects of immune responses, including
lymphoid development, homeostasis, differentiation, tolerance and memory. Interleukin (IL) …

T helper (Th) cell subsets secrete cytokines that regulate other immune cells. Interleukin (IL)-
17 and IL-22 belong to a new class of cytokines with predominant effects on epithelial cells …

Abstract Interleukin (IL-) 27 is a helical cytokine of the greater IL-6/IL-12 family with a broad
range of pro-and anti-inflammatory properties. It can skew T helper cell development …