The protumor roles of alternatively activated (M2) tumor-associated macrophages (TAMs)
have been well established, and macrophage reprogramming is an important therapeutic …

Tumor-associated macrophages (TAMs) can exist in pro-and anti-inflammatory states. Anti-
inflammatory TAMs (also referred to as M2-polarized) generally suppress antitumor immune …

Macrophages are a major component of the tumor microenvironment and orchestrate
various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype …

A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be
predictive for response to contemporary cancer immunotherapies. The generation of a …

Macrophages are the most abundant and one of the most critical cells of tumor immunity.
They provide a bridge between innate and adaptive immunity through releasing cytokines …

Heterotypic interactions between tumor cells and macrophages can enable tumor
progression and hold potential for the development of therapeutic interventions. However …

Macrophages, a type of myeloid immune cell, play essential roles in fighting against
pathogenic invasion and activating T cell-mediated adaptive immune responses. As a major …

Of the multiple unique stromal cell types common to solid tumors, tumor-associated
macrophages (TAMs) are significant for fostering tumor progression. The protumor …

Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated
macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and …

Tumor-associated macrophages (TAMs) are a major component of the tumor immune
microenvironment (TIME) and are associated with a poor prognostic factor in several …