Macrophages are traditional innate immune cells that play critical roles in the clearance of
pathogens and the maintenance of tissue homeostasis. Accumulating evidence proves that …

The tumor microenvironment determines development and progression of many cancers.
Epithelial–mesenchymal transition (EMT) is fundamental to tumor progression and …

During tumor progression, circulating monocytes and macrophages are actively recruited
into tumors where they alter the tumor microenvironment to accelerate tumor progression …

Abstract Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells
and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences …

The majority of current cancer immunotherapy strategies target and potentiate antitumor
adaptive immune responses. Unfortunately, the efficacy of these treatments has been limited …

Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated
macrophages (TAMs), are essential providers of cancer-related inflammation, a condition …

Passive immunotherapy, including adoptive T-cell therapy and antibody therapy, has shown
encouraging results in cancer treatment lately. However, active immunotherapy of solid …

The construction of an inflammatory microenvironment provides the fuel for cancer
development and progression. Hence, solid tumors promote infiltration of leukocyte …

In many solid tumor types, tumor-associated macrophages (TAMs) are important
components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly …

Macrophages are essential components of the inflammatory microenvironment of tumors.
Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs …