Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions
A Mantovani, M Locati - Arteriosclerosis, thrombosis, and vascular …, 2013 - Am Heart Assoc
Macrophages are present in all body compartments, including cancerous tissues, and their
functions are profoundly affected by signals from the microenvironment under homeostatic …
functions are profoundly affected by signals from the microenvironment under homeostatic …
Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
Tumor-infiltrating immune cells can promote chemoresistance and metastatic spread in
aggressive tumors. Consequently, the type and quality of immune responses present in the …
aggressive tumors. Consequently, the type and quality of immune responses present in the …
Tumor-associated macrophages in tumor immunity
Y Pan, Y Yu, X Wang, T Zhang - Frontiers in immunology, 2020 - frontiersin.org
Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune
cell types and are generally categorized into either of two functionally contrasting subtypes …
cell types and are generally categorized into either of two functionally contrasting subtypes …
A breakthrough: macrophage-directed cancer immunotherapy
Successful immunotherapy of cancer is becoming a reality aided by the realization that
macrophages play an important role in the growth or regression of tumors. Specifically …
macrophages play an important role in the growth or regression of tumors. Specifically …
Biology and therapeutic targeting of tumour‐associated macrophages
T Beltraminelli, M De Palma - The Journal of pathology, 2020 - Wiley Online Library
Macrophages sustain tumour progression by facilitating angiogenesis, promoting
immunosuppression, and enhancing cancer cell invasion and metastasis. They also …
immunosuppression, and enhancing cancer cell invasion and metastasis. They also …
Roles of macrophages in tumor development: a spatiotemporal perspective
Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …
Interferon‐γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor‐associated macrophages
D Duluc, M Corvaisier, S Blanchard… - … journal of cancer, 2009 - Wiley Online Library
Tumor‐associated macrophages (TAM) are M2d‐polarized cells (IL‐10high, IL‐12low,
ILT3high, CD86low) that accumulate in tumor microenvironment. TAM inhibit antitumor T …
ILT3high, CD86low) that accumulate in tumor microenvironment. TAM inhibit antitumor T …
The role of macrophages in cancer development and therapy
Simple Summary Tumor-Associated Macrophages (TAMs) play an important role in the
development of tumors, modulation of neoangiogenesis, immune suppression, and …
development of tumors, modulation of neoangiogenesis, immune suppression, and …
Pro-tumorigenic functions of macrophages at the primary, invasive and metastatic tumor site
E Nasrollahzadeh, S Razi, M Keshavarz-Fathi… - Cancer Immunology …, 2020 - Springer
The tumor microenvironment (TME) not only facilitates cancer progression from the early
formation to distant metastasis, but also it differs itself from time to time alongside the tumor …
formation to distant metastasis, but also it differs itself from time to time alongside the tumor …
Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis
PH Lizotte, JR Baird, CA Stevens, P Lauer… - …, 2014 - Taylor & Francis
A principal mechanism by which tumors evade immune-mediated elimination is through
immunosuppression. Previous approaches to tumor immunotherapy have focused on …
immunosuppression. Previous approaches to tumor immunotherapy have focused on …