Cytomegalovirus antiviral drug resistance: future prospects for prevention, detection and management

KE Hanson, S Swaminathan - Future Microbiology, 2015 - Future Medicine
Human cytomegalovirus (CMV) is one of the most important viral pathogens affecting
hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients …

Antiviral drug resistance of human cytomegalovirus

NS Lurain, S Chou - Clinical microbiology reviews, 2010 - Am Soc Microbiol
The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced
knowledge of the virological targets and the mechanisms of antiviral activity. The currently …

Antiviral treatment of cytomegalovirus infection: an update

G Härter, D Michel - Expert opinion on pharmacotherapy, 2012 - Taylor & Francis
This editorial summarizes recent developments in the management of ganciclovir-resistant
human cytomegalovirus (HCMV) infections. All current drugs available for systemic …

Resistance of human cytomegalovirus to antiviral drugs

A Erice - Clinical Microbiology Reviews, 1999 - Am Soc Microbiol
Resistance of cytomegalovirus (CMV) to antiviral agents is a well-recognized phenomenon
that has been observed in the laboratory and in the clinical setting. Infections caused by …

Antiviral treatment of cytomegalovirus infection and resistant strains

A Schreiber, G Härter, A Schubert… - Expert opinion on …, 2009 - Taylor & Francis
This review discusses the management of resistant cytomegalovirus and prevention
strategies for fatal therapy failures. Five drugs, ganciclovir/valganciclovir, cidofovir, foscarnet …

Diversity of antiviral‐resistant human cytomegalovirus in heart and lung transplant recipients

JM Iwasenko, GM Scott, Z Naing… - Transplant Infectious …, 2011 - Wiley Online Library
JM Iwasenko, GM Scott, Z. Naing, AR Glanville, WD Rawlinson. Diversity of antiviral‐
resistant human cytomegalovirus in heart and lung transplant recipients. Transpl Infect Dis …

Definitions of resistant and refractory cytomegalovirus infection and disease in transplant recipients for use in clinical trials

RF Chemaly, S Chou, H Einsele… - Clinical Infectious …, 2019 - academic.oup.com
Despite advances in preventive strategies, cytomegalovirus (CMV) infection remains a major
complication in solid organ and hematopoietic cell transplant recipients. CMV infection may …

Approach to drug-resistant cytomegalovirus in transplant recipients

S Chou - Current opinion in infectious diseases, 2015 - journals.lww.com
Technical advancements can enhance the accurate and timely genotypic detection of drug
resistance. Antivirals undergoing clinical trial offer the prospect of new viral targets and drug …

How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients

KL Springer, S Chou, S Li, RH Giller… - Journal of Clinical …, 2005 - Am Soc Microbiol
Infection with cytomegalovirus (CMV) remains a significant cause of morbidity and mortality
among hematopoietic cell transplant (HCT) recipients. We describe two pediatric HCT …

Cytomegalovirus drug resistance and clinical implications

SW Chou - Transplant Infectious Disease, 2001 - Wiley Online Library
Antiviral agents are commonly used for cytomegalovirus (CMV) prophylaxis or therapy after
solid organ transplantation. Until recently, the detection of drug‐resistant CMV in this setting …