HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave

F Karim, I Gazy, S Cele, Y Zungu, R Krause… - Elife, 2021 - elifesciences.org
There are conflicting reports on the effects of HIV on COVID-19. Here, we analyzed disease
severity and immune cell changes during and after SARS-CoV-2 infection in 236 …

HIV infection alters SARS-CoV-2 responsive immune parameters but not clinical outcomes in COVID-19 disease

F Karim, I Gazy, S Cele, Y Zungu, R Krause… - MedRxiv, 2020 - medrxiv.org
HIV infection alters the immune response and can compromise protective immunity to
multiple pathogens following vaccination. We investigated the impact of HIV on the immune …

Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition

T Nkosi, C Chasara, AO Papadopoulos, TL Nguni… - Elife, 2022 - elifesciences.org
In some instances, unsuppressed HIV has been associated with severe COVID-19 disease,
but the mechanisms underpinning this susceptibility are still unclear. Here, we assessed the …

Immunologic interplay between HIV/AIDS and COVID-19: adding fuel to the flames?

M Augello, V Bono, R Rovito, C Tincati… - Current HIV/AIDS …, 2023 - Springer
Abstract Purpose of Review HIV/AIDS and COVID-19 have been the major pandemics
overwhelming our times. Given the enduring immune disfunction featuring people living with …

Associations between HIV infection and clinical spectrum of COVID-19: a population level analysis based on US National COVID Cohort Collaborative (N3C) data

X Yang, J Sun, RC Patel, J Zhang, S Guo, Q Zheng… - The Lancet …, 2021 - thelancet.com
Background Evidence of whether people living with HIV are at elevated risk of adverse
COVID-19 outcomes is inconclusive. We aimed to investigate this association using the …

[HTML][HTML] HIV/SARS-CoV-2 co-infection: T cell profile, cytokine dynamics and role of exhausted lymphocytes

KS Sharov - International Journal of Infectious Diseases, 2021 - Elsevier
Objectives The aim was to investigate if there is a synergy in HIV and COVID-19 in their
influence upon human immunity; if there is an exacerbation of HIV patients' immune status …

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

A Alrubayyi, E Gea-Mallorquí, E Touizer… - Nature …, 2021 - nature.com
There is an urgent need to understand the nature of immune responses against SARS-CoV-
2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that …

COVID‐19 in people living with HIV: clinical implications of dynamics of the immune response to SARS‐CoV‐2

A Mondi, E Cimini, F Colavita, S Cicalini… - Journal of medical …, 2021 - Wiley Online Library
Little evidence on coronavirus disease 2019 (COVID‐19) in people living with HIV (PLWH)
is currently available. We reported clinical and viroimmunological data of all HIV‐positive …

Impact of chronic HIV infection on SARS-CoV-2 infection, COVID-19 disease and vaccines

Y Yang, A Iwasaki - Current HIV/AIDS Reports, 2022 - Springer
Abstract Purpose of Review The severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has developed into a global pandemic that affect the health of hundreds of millions …

Immune deficiency is a risk factor for severe COVID‐19 in people living with HIV

C Hoffmann, JL Casado, G Härter, P Vizcarra… - HIV …, 2021 - Wiley Online Library
Objectives A prior T cell depletion induced by HIV infection may carry deleterious
consequences in the current COVID‐19 pandemic. Clinical data on patients co‐infected with …