The nuclear receptor peroxisome proliferator-activated receptors (PPARs) are important in
regulating lipid metabolism and inflammatory responses in macrophages. Activation of …

Intracellular lipid accumulation, inflammatory responses, and subsequent apoptosis are the
major pathogenic events of metabolic disorders, including atherosclerosis and nonalcoholic …

Peroxisome proliferator-activated receptor-γ (PPARγ) and liver X receptor-α (LXRα) are
nuclear ligand-activated transcription factors, which regulate lipid metabolism and …

Dysregulation of lipid metabolism is frequently associated with inflammatory conditions. The
mechanism of this association is still not clearly defined. Recently, we identified a nuclear …

Liver X receptors (LXRs) play an important role in lipid metabolism. Recently, a role for these
proteins was identified in suppressing the inflammatory response. However, it is not known …

Lipids and lipid metabolism have well-documented regulatory effects on inflammatory
processes. Recent work has highlighted the role of the peroxisome proliferator-activated …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily that plays a pivotal role in regulating inflammatory gene expression …

Inflammation is a central component of several chronic human diseases, including
atherosclerosis and type 2 diabetes. Several nuclear receptors repress inflammatory …

Objective—Macrophages play a central role in the immune response against infectious
organisms. Once activated, macrophages secrete proinflammatory cytokines and …

Lipid homeostasis and inflammation are key determinants in atherogenesis, exemplified by
the requirement of lipid-laden, foam cell macrophages for atherosclerotic lesion formation …