Diabetic nephropathy (DN) affects at least 30% of insulin dependent diabetic patients
(Andersen et al., 1983) and a lesser percentage of NIDDM subjects (Mogensen, 1984). This …

Kidney disease, characterized by proteinuria and glomerular lesions, is a common
complication of spontaneous diabetes mellitus in many animal species. It occurs in animals …

Diabetic nephropathy in the human is one of the major secondary complications of diabetes.
Diabetic nephropathy is the clinical term used to describe diabetic renal disease when it has …

Accumulating evidence supports intrinsic genetic susceptibility as an important variable in
the progression of diabetic nephropathy in people. Mice provide an experimental platform of …

The lack of an appropriate animal model that spontaneously develops diabetic nephropathy
has been a significant limitation in the search for genetic factors underlying this disease and …

Both type 1 and type 2 diabetes mellitus occur throughout the animal kingdom, and diabetic
kidney disease has often been documented. We have tried to assemble some of the recent …

Diabetic nephropathy is currently the single major cause of kidney failure in the
industrialized world. Animal models have been used in the attempt to develop innovative …

Diabetic nephropathy is the commonest cause of end‐stage renal failure in the western
world. It has been suggested that experimental models of diabetic nephropathy can be used …

Mice provide an experimental model of unparalleled flexibility for studying mammalian
diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the …

Diabetic nephropathy is the major cause of morbidity and premature mortality in individuals
with type-2 diabetes [1, 2]. While it is well established that uncontrolled diabetes underlies …