Cardiac fibroblasts account for about 75% of all cardiac cells, but because of their small size
contribute only∼ 10–15% of total cardiac cell volume. They play a crucial role in cardiac …

Rationale: Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial
fibrillation substrate in congestive heart failure (CHF) by generating tissue fibrosis …

Cardiac fibrosis occurs in a number of cardiovascular diseases associated with a high
incidence of arrhythmias. A critical event in the development of fibrosis is the transformation …

In the healthy heart, cardiac myocytes form an electrical syncytium embedded in a
supportive fibroblast-rich extracellular matrix designed to optimize the electromechanical …

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Atrial fibrosis has
emerged as an important pathophysiological contributor and has been linked to AF …

Atrial fibrosis has been implicated in the development and maintenance of atrial
arrhythmias, and is characterized by expansion of the extracellular matrix and an increased …

Objective Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling,
contributing to the progressive nature of the arrhythmia. Ventricular dysfunction due to a …

Atrial fibrillation (AF) causes substantial morbidity and mortality. It may be triggered and
sustained by either reentrant or nonreentrant electrical activity. Human atrial cellular …

Abstract Development of cardiac fibrosis and arrhythmias is controlled by the activity of and
communication between cardiomyocytes and fibroblasts in the heart. Myocyte-fibroblast …

Aims The pathological proliferation of cardiac fibroblasts (CFs) in response to heart injury
results in fibrosis, which correlates with arrhythmia generation and heart failure. Here we …