Modulation of mitochondrial function through inhibiting respiratory complex I activates a key
sensor of cellular energy status, the 5'-AMP-activated protein kinase (AMPK). Activation of …

Impaired mitochondrial respiratory activity contributes to the development of insulin
resistance in type 2 diabetes. Metformin, a first-line antidiabetic drug, functions mainly by …

Mitochondrial diseases are a clinically heterogenous group of disorders caused by
respiratory chain dysfunction and associated with progressive, multi-systemic phenotype …

Impaired mitochondrial dynamics causes aging-related or metabolic diseases. Yet, the
molecular mechanism responsible for the impairment of mitochondrial dynamics is still not …

Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

Accumulating evidences showed metformin and berberine, well‐known glucose‐lowering
agents, were able to inhibit mitochondrial electron transport chain at complex I. In this study …

Adenosine 5′-monophosphate activated protein kinase (AMPK) is a key enzymatic protein
involved in linking the energy sensing to the metabolic manipulation. It is a serine/threonine …

While it has been known for more than 75 years that physical activity is associated with
increased mitochondrial content in muscle, the molecular mechanism for this adaptive …

Metformin is used as an anti-diabetic drug. Metformin ameliorates insulin resistance by
improving insulin sensitivity in liver and skeletal muscle. Reduced mitochondrial content has …

Objective Skeletal muscle AMP-activated protein kinase (AMPK) is important for regulating
glucose homeostasis, mitochondrial content and exercise capacity. R419 is a mitochondrial …