Immunosenescence: a key player in cancer development
J Lian, Y Yue, W Yu, Y Zhang - Journal of hematology & oncology, 2020 - Springer
Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …
Immunosenescence: molecular mechanisms and diseases
Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - Signal transduction and …, 2023 - nature.com
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
Immune aging and immunotherapy in cancer
M Kaiser, MD Semeraro, M Herrmann… - International Journal of …, 2021 - mdpi.com
Immune functions decline as we age, while the incidence of cancer rises. The advent of
immune checkpoint blockade (ICB) has not only revolutionized cancer therapy, but also …
immune checkpoint blockade (ICB) has not only revolutionized cancer therapy, but also …
Aging, cancer, and antitumor immunity
H Ikeda, Y Togashi - International Journal of Clinical Oncology, 2022 - Springer
Aging leads to numerous changes that affect many components of the immune system,
called “immunosenescence”. Indeed, elderly individuals exhibit dysregulated immune …
called “immunosenescence”. Indeed, elderly individuals exhibit dysregulated immune …
Immunosenescence and cancer
G Pawelec - Biogerontology, 2017 - Springer
Age is a major risk factor for solid cancers, hitherto conventionally viewed in the context of
the cell biology of carcinogenesis. However, if cancers are immunogenic, the immune …
the cell biology of carcinogenesis. However, if cancers are immunogenic, the immune …
Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
X Liu, DF Hoft, G Peng - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
The functional state of the preexisting T cells in the tumor microenvironment is a key
determinant for effective antitumor immunity and immunotherapy. Increasing evidence …
determinant for effective antitumor immunity and immunotherapy. Increasing evidence …
Immunosenescence and cancer
T Fulop, A Larbi, JM Witkowski, R Kotb… - Critical Reviews™ in …, 2013 - dl.begellhouse.com
The immune system, interacting intimately with the cancer cells in a tumor, may combat or
favor cancer development and progression, or both. One of the most important risk factors for …
favor cancer development and progression, or both. One of the most important risk factors for …
Aging, immune senescence, and immunotherapy: a comprehensive review
R Elias, K Hartshorn, O Rahma, N Lin… - Seminars in …, 2018 - Elsevier
The advent of immune checkpoint inhibitors (ICIs) has changed the landscape of cancer
treatment. Older adults represent the majority of cancer patients; however, direct data …
treatment. Older adults represent the majority of cancer patients; however, direct data …
The twilight of the immune system: The impact of immunosenescence in aging
Cellular senescence is a critical part of human anti-tumor defence; however, the
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …
Senescent T cells: a potential biomarker and target for cancer therapy
J Zhang, T He, L Xue, H Guo - EBioMedicine, 2021 - thelancet.com
The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due
to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector …
to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector …