Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

Immune functions decline as we age, while the incidence of cancer rises. The advent of
immune checkpoint blockade (ICB) has not only revolutionized cancer therapy, but also …

Aging leads to numerous changes that affect many components of the immune system,
called “immunosenescence”. Indeed, elderly individuals exhibit dysregulated immune …

Age is a major risk factor for solid cancers, hitherto conventionally viewed in the context of
the cell biology of carcinogenesis. However, if cancers are immunogenic, the immune …

The functional state of the preexisting T cells in the tumor microenvironment is a key
determinant for effective antitumor immunity and immunotherapy. Increasing evidence …

The immune system, interacting intimately with the cancer cells in a tumor, may combat or
favor cancer development and progression, or both. One of the most important risk factors for …

The advent of immune checkpoint inhibitors (ICIs) has changed the landscape of cancer
treatment. Older adults represent the majority of cancer patients; however, direct data …

Cellular senescence is a critical part of human anti-tumor defence; however, the
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …

The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due
to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector …