ID genes have an important function in the cell cycle, and ID proteins may help identify
aggressive tumors, besides being considered promising therapeutic targets. However, their …

The Id (i nhibitor of D NA binding) proteins are a family of helix-loop-helix (HLH) proteins
(Id1, Id2, Id3, and Id4) that lack the basic domain necessary for DNA binding. The Id1 protein …

Background. Members of the Id helix-loop-helix proteins are key regulators of cell growth
and differentiation in a variety of cell types. They are also required for cell cycle progression …

Background. The Id-1 helix-loop-helix protein inhibits differentiation and enhances cell
proliferation. It is required for cell cycle progression. The Id-1 gene is highly expressed in a …

The Id genes encode helix-loop-helix (HLH) transcription proteins that lack a DNA binding
basic domain. Id proteins (Id1, Id2, Id3, and Id4) function as dominant negative regulators of …

A major cause of treatment failure for prostate cancer is the development of androgen-
independent metastatic disease. Id protein family, a group of basic helix–loop–helix …

The molecular signatures of cancer cells have recently been delineated in more detail.
There exist distinct differences in the molecular characteristics of cells derived from a …

Characterisation of molecular mechanisms that control tumour invasion is a crucial step for
the identification of molecular markers to apply in cancer diagnosis and treatment. In this …

Id proteins antagonize basic helix-loop-helix proteins, inhibit differentiation, and enhance
cell proliferation. In this study we compared the expression of Id-1, Id-2, and Id-3 in the …

Id proteins are a class of dominant-negative antagonists of helix-loop-helix transcription
factors and have been shown to control differentiation of a variety of cell types in diverse …