Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis

L Camacho-Barquero, I Villegas… - International …, 2007 - Elsevier
Ulcerative colitis (UC) is a nonspecific inflammatory disorder characterized by oxidative and
nitrosative stress, leucocyte infiltration and up-regulation of pro-inflammatory cytokines …

Curcumin has bright prospects for the treatment of inflammatory bowel disease

H Hanai, K Sugimoto - Current pharmaceutical design, 2009 - ingentaconnect.com
Inflammatory bowel disease (IBD) is a chronic relapsing-remitting condition that afflicts
millions of people throughout the world and impairs their daily functions and quality of life …

Effects of curcumin on apoptosis and oxidoinflammatory regulation in a rat model of acetic acid–induced colitis: The roles of c-Jun N-terminal kinase and p38 mitogen …

Y Topcu-Tarladacalisir, M Akpolat, YH Uz… - Journal of medicinal …, 2013 - liebertpub.com
The present study evaluated the effects of curcumin on epithelial cell apoptosis, the
immunoreactivity of the phospho–c-Jun N-terminal kinase (JNK) and phospho-p38 mitogen …

[HTML][HTML] Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-κB activation

WB Song, YY Wang, FS Meng, QH Zhang, JY Zeng… - PloS one, 2010 - journals.plos.org
Background Intestinal mucosa barrier (IMB) dysfunction results in many notorious diseases
for which there are currently few effective treatments. We studied curcumin's protective effect …

Curcumin as a therapeutic agent for blocking NF-κB activation in ulcerative colitis

Y Wang, Q Tang, P Duan, L Yang - Immunopharmacology and …, 2018 - Taylor & Francis
Ulcerative colitis (UC) is a chronic, relapsing, remitting, and inflammatory disorder that
afflicts millions of people around the world. It carries a substantial economic burden …

Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis

A Lubbad, MA Oriowo, I Khan - Molecular and cellular biochemistry, 2009 - Springer
Curcumin, an active ingredient of Curcumin longa mediates its anti-inflammatory effects
through inhibition of NFkB. Several pathways including toll-like receptors (TLR) induce NFkB …

Curcumin attenuates DNB-induced murine colitis

B Salh, K Assi, V Templeman… - American journal …, 2003 - journals.physiology.org
Numerous therapies used for inflammatory bowel disease (IBD) target the transcription
factor NF-κB, which is involved in the production of cytokines and chemokines integral for …

Curcumin prevents and ameliorates trinitrobenzene sulfonic acid–induced colitis in mice

K Sugimoto, H Hanai, K Tozawa, T Aoshi, M Uchijima… - Gastroenterology, 2002 - Elsevier
Background & Aims: Curcumin is known to have a variety of pharmacologic effects, including
antitumor, anti-inflammatory, and anti-infectious activities. The pleiotropic effects of curcumin …

The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis

N Sadeghi, A Mansoori, A Shayesteh… - Phytotherapy …, 2020 - Wiley Online Library
Background and aims Curcumin has anti‐inflammatory properties. The aim of this study was
to evaluate the effect of curcumin on improvement of the disease activity in ulcerative colitis …

[HTML][HTML] Review of the effects and mechanism of curcumin in the treatment of inflammatory bowel disease

Y Lin, H Liu, L Bu, C Chen, X Ye - Frontiers in Pharmacology, 2022 - frontiersin.org
Curcumin is extracted from the rhizomes of Curcuma longa L. It is now widely used in food
processing, cosmetics, dyes, etc. Current researching indicates that curcumin has high …