[HTML][HTML] Review of experimental animal models of acute pancreatitis

KH Su, C Cuthbertson, C Christophi - Hpb, 2006 - Elsevier
The underlying mechanisms involved in the pathogenesis of acute pancreatitis are ill
understood. The mortality rate of this disease has not significantly improved over the past …

[HTML][HTML] Experimental acute pancreatitis models: history, current status, and role in translational research

X Yang, L Yao, X Fu, R Mukherjee, Q Xia… - Frontiers in …, 2020 - frontiersin.org
Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a
substantial morbidity and mortality. Currently there is no specific treatment for the disease …

Acute pancreatitis: models, markers, and mediators

J Granger, D Remick - Shock, 2005 - journals.lww.com
Acute pancreatitis has an incidence of approximately 40 cases per year per 100,000 adults.
Although usually self-limiting, 10% to 20% of afflicted patients will progress to severe …

[HTML][HTML] Murine models of acute pancreatitis: a critical appraisal of clinical relevance

P Silva-Vaz, AM Abrantes, M Castelo-Branco… - International journal of …, 2019 - mdpi.com
Acute pancreatitis (AP) is a severe disease associated with high morbidity and mortality.
Clinical studies can provide some data concerning the etiology, pathophysiology, and …

Acute pancreatitis: animal models and recent advances in basic research

YC Chan, PS Leung - Pancreas, 2007 - journals.lww.com
Acute pancreatitis (AP) is characterized by edema, acinar cell necrosis, hemorrhage, and
severe inflammation of the pancreas. Patients with AP present with elevated blood and urine …

Pathophysiology and treatment of acute pancreatitis: new therapeutic targets–a ray of hope?

P Felderbauer, C Müller, K Bulut… - Basic & clinical …, 2005 - Wiley Online Library
Acute pancreatitis is a life‐threatening disease with putatively high mortality rates,
particularly in the setting of systemic inflammatory response and multiple organ failure when …

Acute pancreatitis: the substantial human and financial costs

JP Neoptolemos, M Raraty, M Finch, R Sutton - Gut, 1998 - gut.bmj.com
A greater understanding of the natural history of acute pancreatitis combined with greatly
improved radiological imaging has led to improvement in the hospital mortality from acute …

[HTML][HTML] Inflammation and immunosuppression in severe acute pancreatitis

ML Kylänpää, H Repo… - World journal of …, 2010 - ncbi.nlm.nih.gov
Acute pancreatitis (AP) is a common disease, which usually exists in its mild form. However,
in a fifth of cases, the disease is severe, with local pancreatic complications or systemic …

Pathophysiological mechanisms of acute pancreatitis define inflammatory markers of clinical prognosis

GA Minkov, KS Halacheva, YP Yovtchev… - Pancreas, 2015 - journals.lww.com
Abstract Development of acute pancreatitis illustrates the need to understand the basic
mechanisms of disease progression to drive the exploration of therapeutic options …

Organ failure due to systemic injury in acute pancreatitis

PK Garg, VP Singh - Gastroenterology, 2019 - Elsevier
Acute pancreatitis may be associated with both local and systemic complications. Systemic
injury manifests in the form of organ failure, which is seen in approximately 20% of all cases …