The onset of severe acute pancreatitis (SAP) is clinically harmful as it may rapidly progress
from a local pancreatic inflammation into proemial systemic inflammatory reactions. Patients …

Since randomized controlled studies of severe acute human pancreatitis can be performed
only with restrictions, at least some aspects of innovative therapy concepts should first be …

Current findings have provided further insight into the roles and mechanisms of zymogen
activation and inflammatory pathways in pancreatic injury. Future studies, which will be of …

New findings necessitate a paradigm shift in our understanding of acute pancreatitis. Intra-
acinar trypsinogen activation leads to early pancreatic injury, but the inflammatory response …

Acute pancreatitis is currently the most common cause of hospital admission among all
nonmalignant gastrointestinal diseases. To understand the pathophysiology of the disease …

Acute pancreatitis (AP) is a common and potentially lethal acute inflammatory process with a
highly variable clinical course. It is still unclear why some patients progress to organ failure …

Experimental animal models have been employed to study pancreatitis for more than a
century. Although not always related to the disease in humans, they have contributed greatly …

Acute pancreatitis (AP) is a disease characterized by abdominal pain and elevations in the
serum levels of amylase and lipase. 27 A key feature of AP is the elaboration of an …

The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

More treatment modalities that are less invasive became available and a trend towards less
aggressive treatments (fluids, starvation, interventions, opiates) of acute pancreatitis is again …